112778-72-0

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 112778-95-7 (E)-1-(4-Chloro-phenyl)-3-dimethylamino-3-phenyl-propenone 
• 126827-45-0 2-Phenyl-4-p-tolyl-1,4-dihydro-benzo[4,5]imidazo[1,2-a]pyrimidine 
• 956-02-5 4'-chlorochalcone 
• 29540-87-2 1,2-diaminobenzimidazole 
• 19429-87-9 α,α-diethoxy-N,N-dimethylbenzenemethanamine 
• 99-91-2 para-chloroacetophenone 
• 4224-87-7 4-methyl-chalcone 
• 3406-03-9 2-(phenylsulfonyl)acetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 24721-26-4 4-chlorochalcone 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 3240-10-6 (4-chlorophenyl)propiolic acid 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Base-catalyzed one-step synthesis of 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines

We report a practical high-yield synthesis of 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines using a base-assisted cyclocondensation of chalcone and 1,2,4-triazol-3-amine in an open reaction vessel. The same conditions can also be used for the preparation of novel imidazo[1,2-a]pyrimidine derivatives.

Diverse synthesis of pyrimido[1,2-a]benzimidazoles and imidazo[2,1-b]benzothiazoles via CuI-catalyzed decarboxylic multicomponent reactions of heterocyclic azoles, aldehydes and alkynecarboxylic acids

We have developed a straightforward approach to diverse synthesis of 2,3-, 2,4-disubstituted pyrimido [1,2-a]benzimidazoles, 2,4,10-trisubstituted 2,10-dihydropyrimido [1,2-a]benzimidazoles and 2,3-disubstituted imidazo [2,1-b]benzothiazoles via multicomp

An efficient and green synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines using highly active and stable poly acrylic acid-supported layered double hydroxides

A facile and efficient method for the synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines has been achieved via highly active and reusable heterogeneous poly acrylic acid-supported layered double hydroxides (PAA-g-LDHs) catalyst promoted one-pot reaction of 1H-benzo[d]imidazol-2-amine, with α,β-unsaturated carbonyl compounds under solvent-free conditions. PAA-g-LDHs catalyst was successfully synthesized via reversible addition-fragmentation chain-transfer polymerization using grafting reaction and was characterized by different analytical techniques. The significant features of this reaction include expedient one-pot process, short reaction time, excellent yields, wide substrate scope and operational simplicity. Also, the catalyst could be reused for several consecutive runs without any apparent loss in its catalytic activity.

Ultrasound assisted one-pot, three-components synthesis of pyrimido[1,2-a]benzimidazoles and pyrazolo[3,4-b]pyridines: A new access via phenylsulfone synthon

A simple, facile, efficient and three-components procedure for the synthesis of pyrimido[1,2-a]benzimidazoles and pyrazolo[3,4-b]pyridines utilizing phenylsulfone synthon, under ultrasonic irradiation was developed.

CYCLOCONDENSATIONS OF CHALCONES WITH 2-AMINO- AND 1,2-DIAMINOBENZIMIDAZOLES

2,4-Diaryl-1,4-dihydropyrimidobenzimidazoles were obtained by the reaction of 2-aminobenzimidazole with chalcones, and their heteroaromatization was accomplished.The condensation of 1,2-diaminobenzimidazole with unsymmetrically substituted chalcones, which leads to substituted pyrimidobenzimidazoles, was studied.The specificity of this reaction was ascertained by means of alternative synthesis.

A Simple Regioselective Synthesis of Pyrimidobenzimidazoles

2-Aminobenzimidazoles were reacted with enaminones in acetic acid to give pyrimidobenzimidazoles.With a substituted enaminone only one regioisomer was obtained.Structural assignments based on nmr and uv spectroscopy are presented.Possible pathways