112919-41-2

Upstream product

• 67-56-1 methanol 
• 112919-40-1 1-methoxy-2-phenylcyclopropene 
• 2415-80-7 1,1-dichloro-2-phenylcyclopropane 
• 16627-18-2 2-Bromo-3,3-dimethoxy-1-propene 
• 98-80-6 phenylboronic acid 
• 248955-54-6 1,2-dibromo-3,3-dimethoxypropane 
• 6044-68-4 3,3-dimethoxyprop-1-ene 
• 112919-42-3 1-ethoxy-2-phenylcyclopropene 
• 80234-04-4 2-phenylacrylaldehyde diethyl acetal 

Downstream Products

• 1123-85-9 (+)-(R)-2-phenylpropanol 
• 1122103-03-0 1-(2-(dimethoxymethyl)but-3-en-2-yl)benzene 

Relevant academic research and scientific papers

Modular Synthesis of α-Substituted Alkenyl Acetals by a Palladium-Catalyzed Suzuki Reaction of α-Haloalkenyl Acetals with Organoboranes

A modular and straightforward synthetic strategy for the preparation of α-substituted alkenyl acetals has been developed. α-Haloalkenyl acetals react smoothly with (het)aryl boronic acids, aryl boronates, or B-Alkyl-9-borabicyclo[3.3.1]nonanes through Pd-catalyzed Suzuki cross-coupling under mild conditions with good to high yields. This protocol features a broad substrate scope and good functional-group compatibility, and is easily scaled up.