1132940-51-2

Basic information

• Product Name: 1-(Tert-butyl)-3,5-diiodo-2-methoxybenzene
• Synonyms: 1-(TERT-BUTYL)-3,5-DIIODO-2-METHOXYBENZENE;1132940-51-2;1-tert-butyl-3,5-diiodo-2-methoxybenzene;SCHEMBL351682;PBISNKVQOXSGFO-UHFFFAOYSA-N;DTXSID901335211;AM808010;FT-0733741;A907408;1,5-Diiodo-2-methoxy-3-(2-methyl-2-propanyl)benzene
• CAS NO: 1132940-51-2
• Molecular Weight: 416.041
• Mol File: 1132940-51-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(Tert-butyl)-3,5-diiodo-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Tert-butyl)-3,5-diiodo-2-methoxybenzene(1132940-51-2)
• EPA Substance Registry System: 1-(Tert-butyl)-3,5-diiodo-2-methoxybenzene(1132940-51-2)

Safety Data

• Hazardous Substances Data: 1132940-51-2(Hazardous Substances Data)

Usage

General Description

1-(Tert-butyl)-3,5-diiodo-2-methoxybenzene is a chemical compound with the molecular formula C11H14I2O. It is a white to off-white crystalline powder with a molecular weight of 406.04 g/mol. 1-(Tert-butyl)-3,5-diiodo-2-methoxybenzene is commonly used in organic synthesis and pharmaceutical research due to its potential as a building block in the production of various drugs and biologically active molecules. It is known for its high reactivity and ability to undergo various chemical reactions, making it a valuable tool in the development of new compounds and materials. However, it is important to handle this compound with caution, as it can be harmful if ingested, inhaled, or absorbed through the skin, and should be used in a controlled laboratory setting by trained professionals.

Upstream product

• 74-88-4 methyl iodide 
• 60803-26-1 2-(tert-butyl)-4,6-diiodophenol 
• 88-18-6 2-tert-Butylphenol 
• 39068-23-0 sodium 2-tert-butylphenolate 

Downstream Products

• 1132940-53-4 1-(3-tert-butyl-5-iodo-4-methoxyphenyl)-2,4-dihydropyrimidine-2,4(1H,3H)-dione 
• 1132935-63-7 N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide 
• 1355646-97-7 6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 1355646-93-3 1-(3-tert-butyl-5-(6-hydroxynaphthalen-2-yl)-4-methoxyphenyl)-pyrimidine-2,4(1H,3H)-dione 
• 1245899-21-1 2,4-di-tert-butoxy-5-(3-tert-butyl-5-iodo-4-methoxyphenyl)pyrimidine 
• 1245899-24-4 1-(3-tert-butyl-5-iodo-4-methoxyphenyl)pyrrolidin-2-one 
• 1245899-28-8 1-tert-butyl-3-iodo-2-methoxy-5-(1-phenylvinyl)benzene 
• 1245899-26-6 1-(3-tert-butyl-5-iodo-4-methoxyphenyl)pyridin-2(1H)-one 

Relevant articles and documents

Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor

Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed. First, the copper-catalyzed coupling of uracil with aryl iodides, employing picolinamide 16 as the ligand, was discovered. Later, the palladium-catalyzed sulfonamidation of aryl nonaflate 33 was developed, promoted by electron-rich palladium complexes, including the novel phosphine ligand, VincePhos (50). This made possible a convergent, highly efficient synthesis of dasabuvir that significantly reduced the mutagenic impurity burden of the process.

PROCESS FOR PREPARING ANTIVIRAL COMPOUND

This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.