60803-26-1

Usage

Uses

Used in Organic Synthesis:
2-(tert-butyl)-4,6-diiodophenol is utilized as a reagent in organic synthesis for the preparation of various organic compounds. Its unique structure with iodine atoms and a tert-butyl group allows for versatile reactions and the formation of a wide range of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(tert-butyl)-4,6-diiodophenol is used as a building block for the synthesis of pharmaceutical compounds. Its presence in the molecular structure can contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-(tert-butyl)-4,6-diiodophenol is employed in the agrochemical industry for the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties make it a valuable component in the development of effective and targeted agrochemical products.
Used in Materials Science:
In the field of materials science, 2-(tert-butyl)-4,6-diiodophenol is used as a building block for the development of new materials with specific properties. Its unique structure can contribute to the creation of materials with improved performance in various applications.
It is crucial to handle and use 2-(tert-butyl)-4,6-diiodophenol with proper safety precautions due to its potential hazards.

Upstream product

• 88-18-6 2-tert-Butylphenol 
• 39068-23-0 sodium 2-tert-butylphenolate 

Downstream Products

• 364068-80-4 acetic acid 2-tert-butyl-4,6-diiodo-phenyl ester 
• 1132940-51-2 1-tert-butyl-3,5-diiodo-2-methoxybenzene 
• 60803-25-0 2-(tert-butyl)-4-iodophenol 
• 1355646-93-3 1-(3-tert-butyl-5-(6-hydroxynaphthalen-2-yl)-4-methoxyphenyl)-pyrimidine-2,4(1H,3H)-dione 
• 1355646-97-7 6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 1132935-63-7 N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide 
• 1132940-53-4 1-(3-tert-butyl-5-iodo-4-methoxyphenyl)-2,4-dihydropyrimidine-2,4(1H,3H)-dione 
• 364068-82-6 carbonic acid tert-butyl ester 2-tert-butyl-6-iodo-4-[(triisopropylsilanyl)-ethynyl]-phenyl ester 
• 364068-81-5 acetic acid 2-tert-butyl-6-iodo-4-[(triisopropylsilanyl)-ethynyl]-phenyl ester 

Relevant academic research and scientific papers

Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor

Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed. First, the copper-catalyzed coupling of uracil with aryl iodides, employing picolinamide 16 as the ligand, was discovered. Later, the palladium-catalyzed sulfonamidation of aryl nonaflate 33 was developed, promoted by electron-rich palladium complexes, including the novel phosphine ligand, VincePhos (50). This made possible a convergent, highly efficient synthesis of dasabuvir that significantly reduced the mutagenic impurity burden of the process.

Synthesis of (-)-Piperitylmagnolol Featuring ortho-Selective Deiodination and Pd-Catalyzed Allylation

A 1,4-addition strategy using an enone and a copper reagent was studied for the synthesis of (-)-piperitylmagnolol. A MOM-protected biphenol copper reagent was added to BF3·OEt2-activated 4-isopropylcyclohexenone, whereas 1,4-addition of protected monophenol reagents possessing an allyl group was found to be unsuccessful. The allyl group was later attached to the p-,p′-diiodo-biphenol ring by Pd-catalyzed coupling with allylborate. The aforementioned iodide was synthesized using a new method for ortho-selective deiodination of o-,p-diiodophenols.

PROCESS FOR PREPARING ANTIVIRAL COMPOUNDS

This disclosure is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

PROCESS FOR PREPARING ANTIVIRAL COMPOUND

This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such interm

URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C

Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Benzofuran Trimers for Organic Electroluminescence

Four linear benzofuran trimers have been prepared by a two-stage synthetic procedure. They were tested as materials for organic electroluminescence (OEL). Precursor phenylene ethynylene oligomers were formed in the first stage, then after removal of the p