1133-77-3

Usage

Uses

Used in Organic Chemistry:
1-Phenyl-1H-pyrazole-5-carboxylic acid is used as a precursor or intermediate in chemical synthesis for [application reason]. Its unique structural configuration and property setup make it a valuable component in the creation of various organic compounds.
Used in Medicinal Chemistry:
1-Phenyl-1H-pyrazole-5-carboxylic acid is used as a building block in the development of pharmaceutical drugs for [application reason]. Its derivatives are widely prevalent in medicinal chemistry, contributing to the design and synthesis of novel therapeutic agents.
Used in Pharmaceutical Drug Development:
1-Phenyl-1H-pyrazole-5-carboxylic acid is used as a key component in the synthesis of pharmaceutical drugs for [application reason]. Its versatile chemical properties and reactivity enable the creation of a wide range of drug candidates with potential therapeutic applications.

InChI:InChI=1/C10H8N2O2/c13-10(14)9-6-7-11-12(9)8-4-2-1-3-5-8/h1-7H,(H,13,14)

Upstream product

• 93323-27-4 (E)-1-phenyl-5-styryl-1H-pyrazole 
• 109-72-8 n-butyllithium 
• 124-38-9 carbon dioxide 
• 1126-00-7 1-phenylpyrazole 
• 115315-94-1 ethyl 1-phenyl-1H-pyrazole-5-carboxylate 
• 854700-36-0 5-(4-nitro-phenyl)-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 62089-28-5 5-(4-nitrophenyl)-1-phenyl-1H-pyrazole 
• 100-63-0 phenylhydrazine 
• 10199-57-2 5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 60-29-7 diethyl ether 
• 62089-29-6 4-(2-phenyl-2H-pyrazol-3-yl)-aniline 
• 91565-82-1 1-phenyl-5-propyl-1H-pyrazole 
• 6831-91-0 5-methyl-1-phenylpyrazole 
• 108-86-1 bromobenzene 

Downstream Products

• 55115-07-6 1-Phenylpyrazol-5-carbonsaeure-methylester 
• 1293280-52-0 2-(4,6-dimethylpyrimidin-2-yl)-5-[(1-phenyl-1H-pyrazol-5-yl)carbonyl]octahydropyrrolo[3,4-c]pyrrole 
• 423768-37-0 1-phenyl-1H-pyrazole-5-carbonyl chloride 

Relevant academic research and scientific papers

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design

Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the genes that codify cysteine biosynthetic enzymes. Therefore, inhibition of cysteine biosynthesis has emerged as a promising strategy to find new potential agents for the treatment of bacterial infection. Following our previous efforts to explore OASS inhibition and to expand and diversify our library, a scaffold hopping approach was carried out, with the aim of identifying a novel fragment for further development. This novel chemical tool, endowed with favourable pharmacological characteristics, was successfully developed, and a preliminary Structure–Activity Relationship investigation was carried out.

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

The synthesis, evaluation, and structure-activity relationships of a class of acyl guanidines which inhibit the BACE-1 enzyme are presented. The prolinyl acyl guanidine chemotype (7c), unlike compounds of the parent isothiazole chemotype (1), yielded compounds with good agreement between their enzymatic and cellular potency as well as a reduced susceptibility to P-gp efflux. Further improvements in potency and P-gp ratio were realized via a macrocyclization strategy. The in vivo profile in wild-type mice and P-gp effects for the macrocyclic analog 21c is presented.