113502-46-8

Upstream product

• 110960-73-1 ethyl 4-methylpyrimidine-5-carboxylate 
• 100-63-0 phenylhydrazine 
• 2290-03-1 methyl N'-phenylhydrazinoformate 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 6078-46-2 ethyl 3-(2-phenylhydrazono)butanoate 
• 68-12-2 N,N-dimethyl-formamide 
• 121902-77-0 phenylhydrazone de l'acetyl-5 uracile 
• 6214-65-9 5-acetyluracil 
• 64-17-5 ethanol 
• 121902-76-9 allophanoyl-4 methyl-3 phenyl-1 pyrazole 
• 6214-64-8 ethyl 4-methyl-2-oxo-1H-pyrimidine-5-carboxylate 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 77169-11-0 3-Methyl-1-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF PYRAZOLES

A process is described for the synthesis of pyrazoles having general formula (I) which comprises the steps of mixing a compound having general formula (II) and a 1,2-disubstituted hydrazine having general formula (III) to form a reaction intermediate having general formula (IV) and the reaction mixture obtained in step i), in an acid environment, cyclizes to form a pyrazole having general formula (I), according to reaction scheme 1 Scheme 1.

Reaction of hydrazones derived from active methylene compounds with Vilsmeier-Haack reagent

Reaction of hydrazones derived from active methylene compounds with the Vilsmeier-Haack reagent was studied. Compounds with sulfone, ester, nitrile, triphenylphosphonium, and phthalimide moieties were evaluated. It was found that electron-withdrawing and

CONVERSION DE L'ACETYL-5 URACILE EN DERIVES PYRAZOLIQUES PAR L'HYDRAZINE ET LES HYDRAZINES MONOSUBSTITUEES

5-Acetyl uracile 1 is easily transformed by hydrazine and methylhydrazine into 4-allophanoyl-3-methyl pyrazole 2 (R=H) and 4-allophanoyl-1,3-dimethyl pyrazole 2 (R=CH3).The pyrazoles 2, in boiling butanol and in the presence of hydrochloric acid lead resp

Synthese regiospecifique d'acyl-4 pyrazoles a partir d'acyl-5 pyrimidines

The transformation of variously substituted 5-acetyl-4-methylpyrimidines 1 into 4-acetyl-1-amidino-3-methylpyrazole amidinohydrazone dihydrochloride 3, under the action of amidinohydrazine hydrochloride, in boiling acidic methanolic solution, depends on the nature of the 2-substituent of pyrimidines 1, and on the stability of the amidinohydrazone of pyrimidines 2 under the reaction conditions.Phenylhydrazine transforms all the pyrimidines 1 into pyrazoles, regiospecifically or not, according to the nature of the 2-substituent of pyrimidines 1.This new possibility of ring contraction has been extended to other unsymetrical 5-acyl- and 5-ethoxycarbonylpyrimidines.