1135531-76-8Relevant articles and documents
NEW BIARYL AMIDE DERIVATIVES
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Page/Page column 38-39, (2012/07/14)
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.
Process development of a potent bradykinin 1 antagonist
Menzel, Karsten,Machrouhi, Fouzia,Bodenstein, Matthew,Alorati, Anthony,Cowden, Cameron,Gibson, Andrew W.,Bishop, Brian,Ikemoto, Norihiro,Nelson, Todd D.,Kress, Michael H.,Frantz, Doug E.
experimental part, p. 519 - 524 (2010/04/22)
As part of Merck's continued research effort on inflammation and pain, a safe synthesis of an orally bioavailable and CNS penetrant bradykinin 1 antagonist was developed and demonstrated on kilogram scale. The key step included a novel regioselective meta