1135531-77-9

Upstream product

• 1135531-76-8 N-[(1R)-1-{5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-3-fluoropyridin-2-yl}ethyl]acetamide 
• 858414-24-1 2-bromo-4-chloro-6-fluoro-N-hydroxy-benzamidine 
• 1135531-74-6 1-(2-bromo-4-chloro-6-fluorophenyl)-N-hydroxymethanimine 
• 208186-78-1 1,2-dibromo-5-chloro-3-fluorobenzene 
• 1135531-73-5 2-bromo-4-chloro-6-fluorobenzaldehyde 
• 858414-23-0 3-(2-bromo-4-chloro-6-fluorophenyl)-5-methyl-[1,2,4]oxadiazole 
• 858414-21-8 N-[(1R)-1-(5-bromo-3-fluoropyridin-2-yl)ethyl]acetamide 
• 886373-28-0 5-bromo-3-fluoropyridine-2-carbonitrile 
• 573675-25-9 5-bromo-3-nitropyridine-2-carbonitrile 
• 15862-37-0 2,5-dibromo-3-nitro-pyridine 
• 15862-34-7 5-bromo-3-nitro-2-pyridone 
• 858414-26-3 tert-butyl ((1R)-1-{5-[5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-3-fluoropyridin-2-yl}ethyl)carbamate 

Downstream Products

• 1217888-68-0 C₁₈H₁₆ClF₂N₅O₃ 
• 1384170-93-7 3-(3-fluoro-5-(trifluoromethyl)-benzoylamino)-oxetane-3-yl-carboxylic acid ((R)-1-{5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-3-fluoro-pyridin-2-yl}-ethyl)-amide 
• 1384170-94-8 3-(2,2,2-trifluoro-acetylamino)-oxetane-3-carboxylic acid ((R)-1-{5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-3-fluoro-pyridin-2-yl}-ethyl)-amide 
• 1384171-37-2 3-amino-oxetane-3-carboxylic acid ((R)-1-{5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-3-fluoro-pyridin-2-yl}-ethyl)-amide 
• 1384171-39-4 [3-((R)-1-{5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-3-fluoro-pyridin-2-yl}-ethylcarbamoyl)-oxetan-3-yl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 1240133-35-0 C₂₄H₂₇ClF₂N₆O₄ 

Relevant academic research and scientific papers

NEW BIARYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.

NEW BIARYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.

Novel small molecule bradykinin B1 receptor antagonists. Part 1: Benzamides and semicarbazides

The synthesis and SAR of two series of bradykinin B1 receptor antagonists is described. The benzamide moiety proved to be a suitable replacement for the aryl ester functionality of biaryl based antagonists. In addition, it was found that semica

Process development of a potent bradykinin 1 antagonist

As part of Merck's continued research effort on inflammation and pain, a safe synthesis of an orally bioavailable and CNS penetrant bradykinin 1 antagonist was developed and demonstrated on kilogram scale. The key step included a novel regioselective meta