113675-86-8

Upstream product

• 102-92-1 Cinnamoyl chloride 
• 24221-86-1 (+)-(1S,2R)-ephedrine hydrochloride 
• 102-92-1 cinnamoyl chloride 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 128947-02-4 (4R,5S)-1,5-dimethyl-3-[(2E)-3-phenyl-2-propenoyl]-4-phenyl-2-imidazolidinone 
• 128947-01-3 (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone 
• 100-59-4 phenylmagnesium chloride 
• 75-16-1 methylmagnesium bromide 

Relevant academic research and scientific papers

Asymmetric 1,4-addition of Grignard reagents to chiral α,β-unsaturated imides in the presence of Lewis acids

The asymmetric 1,4 addition of PhMgCl, MeMgBr and allylMgBr to chiral imides 1 has been studied under various conditions. The presence of a Lewis acid, as AlMe2Cl, affords an enhanced diastereoselectivity favouring the formation of the product derived from the attack on the re face. The 1,4 addition of allyl diisopropoxyborate to imides 1 has also been analysed.

Diastereoselective additions of alkyl, akenyl, aryl and allyl cuprates to unsaturated chiral imides

Some diastereoselective conjugate additions of cuprates to chiral unsaturated imides bearing an imidazolidinyl group (from ephedrine and urea) show an impressive stereoselectivity. The chiral (internal auxiliary dependent) group is easily broken and recyc