1138123-83-7Relevant articles and documents
CHEMOENZYMATIC METHODS FOR SYNTHESIZING MOENOMYCIN ANALOGS
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, (2013/10/22)
The present invention provides methods of synthesizing moenomycin analogs of Formula (I). The present invention also provides compositions comprising a compound of Formula (I) and kits for synthesizing compounds of Formula (I).
Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors
Gampe, Christian M.,Tsukamoto, Hirokazu,Doud, Emma H.,Walker, Suzanne,Kahne, Daniel
, p. 3776 - 3779 (2013/04/23)
New antibiotic drugs need to be identified to address rapidly developing resistance of bacterial pathogens to common antibiotics. The natural antibiotic moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases
METHODS AND COMPOUNDS FOR IDENTIFYING GLYCOSYLTRANSFERASE INHIBITORS
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, (2013/10/22)
The present invention provides moenomycin-based probe compounds of Formula (I) for use in screening inhibitors of bacterial glycosyltransferases. The present invention also provides bacterial glycosyltransferase screening assays using compounds of Formula (I).