176299-96-0Relevant articles and documents
Convergent Synthesis of Digalactosyl Diacylglycerols
Inuki, Shinsuke,Kishi, Junichiro,Kashiwabara, Emi,Aiba, Toshihiko,Fujimoto, Yukari
, p. 6482 - 6485 (2017)
Efficient convergent chemical syntheses of digalactosyl diacylglycerols (DGDGs), which have both a galactose-galactose α(1→6)-linkage and a galactose-glycerol β-linkage along with a diacylglycerol containing various kinds of fatty acids, have been accomplished. In order to achieve a concise synthesis, we chose to use allylic protective groups as permanent protective groups. We have also achieved α- and β-selective glycosylations for the respective linkages with high yields as the key steps.
Studies towards the total synthesis of repeating unit of O-sulfated polysaccharide from marine bacterium Cobetia pacifica KMM 3878
Pradhan, Kabita,Podilapu, Ananda Rao,Kulkarni, Suvarn S.
, p. 255 - 264 (2020/03/18)
Herein we report assembly of the appropriately protected trisaccharide repeating unit of Cobetia pacifica KMM 3878 O-sulfated polysaccharide. Our synthesis involves 3,4-O-pyruvilated galactose as the key building block which acts as a donor as well as acceptor in the construction of trisaccharide. We obtained the R isomer as a major stereoisomer in the pyruvilation reaction. The glycosylations proceeded with high stereo and regioselectivity.
Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors
Gampe, Christian M.,Tsukamoto, Hirokazu,Doud, Emma H.,Walker, Suzanne,Kahne, Daniel
, p. 3776 - 3779 (2013/04/23)
New antibiotic drugs need to be identified to address rapidly developing resistance of bacterial pathogens to common antibiotics. The natural antibiotic moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases