1138124-35-2Relevant academic research and scientific papers
METHODS AND COMPOUNDS FOR IDENTIFYING GLYCOSYLTRANSFERASE INHIBITORS
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Paragraph 00253-00254, (2013/10/22)
The present invention provides moenomycin-based probe compounds of Formula (I) for use in screening inhibitors of bacterial glycosyltransferases. The present invention also provides bacterial glycosyltransferase screening assays using compounds of Formula (I).
CHEMOENZYMATIC METHODS FOR SYNTHESIZING MOENOMYCIN ANALOGS
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Paragraph 00174; 00175, (2013/10/22)
The present invention provides methods of synthesizing moenomycin analogs of Formula (I). The present invention also provides compositions comprising a compound of Formula (I) and kits for synthesizing compounds of Formula (I).
Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors
Gampe, Christian M.,Tsukamoto, Hirokazu,Doud, Emma H.,Walker, Suzanne,Kahne, Daniel
, p. 3776 - 3779 (2013/04/23)
New antibiotic drugs need to be identified to address rapidly developing resistance of bacterial pathogens to common antibiotics. The natural antibiotic moenomycin A is the prototype for compounds that bind to bacterial peptidoglycan glycosyltransferases
MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF
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Sheet 45, (2009/05/30)
The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin a
