113932-79-9Relevant academic research and scientific papers
A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
Palmieri, Alessandro,Ley, Steven V.,Hammond, Kelvin,Polyzos, Anastasios,Baxendale, Ian R.
, p. 3287 - 3289 (2009)
We report on the use of commercially available chemical microreactors to effect the Hofmann rearrangement of aromatic amides to the corresponding carbamates. Crown Copyright
NEW METHOD FOR HOFMANN REARRANGEMENT
Jew, Sang-sup,Park, Hyeung Geun,Park, Hee-Joo,Park, Min-soo,Cho, Youn-sang
, p. 1559 - 1562 (1990)
Treatment of a series of primary aliphatic and aromatic carboxamides (1a-1m) with NBS-Hg(OAc)2-R'OH (A), dibromantin-Hg(OAc)2-R'OH (B), NBS-AgOAc-R'OH (C), or dibromantin-AgOAc-R'OH (D) in DMF under argon provides corresponding carbamates (2a-2m) in nearly quantitative yields.
Hofmann Rearrangement of Carboxamides Mediated by N-Bromoacetamide
Jevti?, Ivana I.,Do?en-Mi?ovi?, Ljiljana,Ivanovi?, Evica R.,Ivanovi?, Milovan D.
, p. 1550 - 1560 (2016/06/01)
An efficient, one-pot procedure for the Hofmann rearrangement of aromatic and aliphatic amides has been developed. Methyl and benzyl carbamates are produced with N-bromoacetamide in the presence of lithium hydroxide or lithium methoxide, in high yields. β-Phenylamino amides gave five-membered cyclic ureas stereospecifically. Side products of aryl or benzyl bromination were minimized. This procedure offers an easy access to various protected amines or diamines, which represent important synthetic precursors.
