114-91-0Relevant academic research and scientific papers
Catalytic Amination of β-(Hetero)arylethyl Ethers by Phosphazene Base t-Bu-P4
Shigeno, Masanori,Nakamura, Ryutaro,Hayashi, Kazutoshi,Nozawa-Kumada, Kanako,Kondo, Yoshinori
, p. 6695 - 6699 (2019/09/07)
We describe the catalytic amination of β-(hetero)arylethyl ethers with amines using the organic superbase t-Bu-P4 to obtain β-(hetero)arylethylamines. The reaction has a broad substrate scope and allows the transformations of electron-deficient and electron-neutral β-(hetero)arylethyl ethers with various amines including pyrrole, N-alkylaniline, diphenylamine, aniline, indole, and indoline derivatives. Mechanistic studies indicate a two-reaction pathway of MeOH elimination from the substrate to form a (hetero)arylalkene followed by the hydroamination of the alkene.
First Cobalt(I)-catalysed Heterocyclotrimerization of Ethyne with Nitriles to Pyridines in Water under Mild Conditions
Heller, Barbara,Oehme, Guenther
, p. 179 - 180 (2007/10/02)
In water the synthesis of substituted pyridines with cobalt(I)-complexes is carried out at room temperature and normal pressure with very high product selectivity in the presence of light.
Photoinduced Alkoxylation of 2-Vinylpyridinium Ion
Ishida, Akito,Uesugi, Tatsumi,Takamuku, Setsuo
, p. 1580 - 1582 (2007/10/02)
Photoirradiation of 2-vinylpyridine in acidic methanol afforded methyl 2-(2-pyridyl)ethylether in a high yield.Reactions in acetic ethanol and 2-propanol also provided the corresponding alkoxyl derivatives along with a considerable amount of 2-ethylpyridine.It was suggested that photoinduced intramolecular charge-shift from the pyridinium ion moiety into the vinyl group initiates the regioselective nucleophilic addition of alcohol.
Alkylation of Pyridine in Free Radical Chain Reactions Utilizing Alkylmercurials
Russell, Glen A.,Guo, Deliang,Khanna, Rajive K.
, p. 3423 - 3425 (2007/10/02)
Pyridines or N,N,N',N'-tetramethyl-p-phenylenediamine will undergo a photostimulated free radical chain reaction with alkylmercury halides or carboxylates, yielding ring alkylated substitution products.Alkene mercuration products (R1CH(Y)CH(R2)HgX with Y=HO, RO, CH3CONH; X=Cl, CH3CO2, CF3CO2) can be used without isolation for the alkylation reaction
SYNTHESIS OF FUNCTIONALLY SUBSTITUTED PYRIDINES AND DIPYRIDYL-SUBSTITUTED COMPOUNDS WITH THE AID OF LOW-VALENCE COMPOLEXES
Selimov, F. A.,Khafizov, V. R.,Dzhemilev, U. M.
, p. 290 - 295 (2007/10/02)
The possibility of the preparation of oxygen, nitrogen, and sulfur-containing pyridines and dipyridyl-substituted compounds by the cyclocotrimerization of substituted propionitriles with acetylene under the influence of a Co(2-ethylhexanoate)2-Al(C2H5)3 catalyst was demonstrated.It was established that the nature of the heteroatom in substituted propionitriles has virtually no effect on the direction of the reaction.
