114045-96-4

Basic information

• Product Name: 4-Benzyloxy-2-fluorobenzoic ac
• Synonyms: 4-Benzyloxy-2-fluorobenzoic ac;4-Benzyloxy-2-fluorobenzoic acid, 98%
• CAS NO: 114045-96-4
• Molecular Formula: C₁₄H₁₁FO₃
• Molecular Weight: 246.236
• Mol File: 114045-96-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 165-168℃
• Boiling Point: 380.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.289±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.53±0.10(Predicted)
• CAS DataBase Reference: 4-Benzyloxy-2-fluorobenzoic ac(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzyloxy-2-fluorobenzoic ac(114045-96-4)
• EPA Substance Registry System: 4-Benzyloxy-2-fluorobenzoic ac(114045-96-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 114045-96-4(Hazardous Substances Data)

Usage

General Description

4-Benzyloxy-2-fluorobenzoic acid is a chemical compound with the molecular formula C14H11FO3. It is an organic compound that contains a benzene ring with a fluoro substituent and a benzyloxy group. It is commonly used as a building block in organic synthesis, and it has potential applications in the pharmaceutical industry for the development of new drugs. 4-Benzyloxy-2-fluorobenzoic ac can be used as a precursor in the synthesis of various biologically active compounds and pharmaceutical intermediates. It is important to handle this compound with care and use proper safety precautions due to its potential hazards and toxicity.

Upstream product

• 100-39-0 benzyl bromide 
• 65145-13-3 2-fluoro-4-hydroxybenzoic acid 
• 898563-93-4 4-benzyloxy-2-fluoro-benzoic acid benzyl ester 
• 100-44-7 benzyl chloride 
• 185346-79-6 4-(benzyloxy)-1-bromo-2-fluorobenzene 
• 372-20-3 3-fluorophenol 
• 217978-01-3 ethyl-2-fluoro-4-hydroxy-benzoate 
• 121219-03-2 4-bromo-3-fluorophenol 
• 124-38-9 carbon dioxide 
• 185836-35-5 2-fluoro-4-phenylmethoxybenzonitrile 

Downstream Products

• 356058-46-3 (S)-(+)-2-methylbutyl 4-benzyloxy-2-fluorobenzoate 
• 239803-48-6 (R)-(-)-1-methylheptyl 4-benzyloxy-2-fluorobenzoate 
• 636794-07-5 4-Benzyloxy-N-cyanomethyl-2-fluoro-benzamide 
• 636794-12-2 4-Benzyloxy-2-fluoro-N-(2-methoxy-ethyl)-benzamide 
• 636794-02-0 2-[4-benzyloxy-2-fluoro-benzamido]acetamide 
• 356058-47-4 1-propylbutyl 4-benzyloxy-2-fluorobenzoate 
• 1594109-78-0 C₂₁H₁₄F₄O₄ 

Relevant articles and documents

Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8

Endosomal toll-like receptors (TLRs) 7 and 8 recognize viral single-stranded RNAs, a class of imidazoquinoline compounds, 8-oxo-adenosines, 8-aminobenzodiazepines, pyrimidines, and guanosine analogues. Substantial evidence is present linking chronic inflammation mediated specifically by TLR7 to the progression of autoimmunity. We identified a new TLR7/8 dual inhibitor (1) and a TLR8-specific inhibitor (2) based on our previous screen targeting TLR8. Compound 1, bearing a benzanilide scaffold, was found to inhibit TLR7 and TLR8 at low micromolar concentrations. We envisioned making modifications on the benzanilide scaffold of 1 resulting in a class of highly specific TLR7 inhibitors. Our efforts led to the discovery of a new TLR8 inhibitor (CU-115) and identification of a TLR7/8 dual inhibitor (CU-72), bearing a distinct diphenyl ether skeleton, with potential for TLR7 selectivity optimization. Given the role of TLR8 in autoimmunity, we also optimized the potency of 2 and developed a new TLR8 inhibitor bearing a 1,3,4-oxadiazole motif.

BICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS

The invention pertains to bicyclic heteroaryl compounds that serve as effective phosphodiesterase (PDE) inhibitors The invention also relates to compounds which are selective inhibitors of PDE-10. The invention further relates to intermediates for prepara

FLUOROBENZAMIDES

The present invention is concerned with fluorobenzamide derivatives of the general formula Wherein R1 is hydrogen, (C1-C6)-alkyl or hydroxy-(C1-C6)-alkyl; R2 is (C1-C6/su