1140917-50-5

Basic information

• Product Name: (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide
• Synonyms: (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide
• CAS NO: 1140917-50-5
• Molecular Weight: 413.415
• Mol File: 1140917-50-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide(1140917-50-5)
• EPA Substance Registry System: (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide(1140917-50-5)

Safety Data

• Hazardous Substances Data: 1140917-50-5(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 1141016-83-2 (R)-3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine 
• 115029-23-7 2-fluoro-5-(trifluoromethyl)benzoic acid 
• 59997-51-2 trimethylacetylacetonitrile 
• 207981-46-2 2-fluoro-5-(trifluoromethyl)benzoyl chloride 
• 1140917-98-1 (R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine hydrochloride 
• 1140917-39-0 (R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine 

Downstream Products

• 1217406-00-2 methyl 3-[2-[({(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}amino)carbonyl]-4-(trifluoromethyl)phenoxy]-2,2-dimethylpropanoate 
• 1140917-51-6 N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-2-fluoro-5-(trifluoromethyl)benzamide 

Relevant articles and documents

The discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine cannabinoid type 2 receptor agonist

The development of selective CB2 receptor agonists is a promising therapeutic approach for the treatment of inflammatory diseases, without CB1 receptor mediated psychoactive side effects. Preliminary structure-activity relationship studies on pyrazoylidene benzamide agonists revealed the -ylidene benzamide moiety was crucial for functional activity at the CB2 receptor. A small library of compounds with varying linkage moieties between the pyrazole and substituted phenyl group has culminated in the discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine agonist 19 (CB2R EC50 = 19 nM, CB1R EC50 > 10 μM). Docking studies have revealed key structural features of the linkage group that are important for potent functional activity.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are cannabinoid receptor ligands of formula (I) wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.