115290-77-2

Basic information

• Product Name: 1,3-Propanediol, 1-phenyl-, 3-methanesulfonate, (S)-
• CAS NO: 115290-77-2
• Molecular Formula: C10H14O4S
• Molecular Weight: 230.285
• Mol File: 115290-77-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-Propanediol, 1-phenyl-, 3-methanesulfonate, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanediol, 1-phenyl-, 3-methanesulfonate, (S)-(115290-77-2)
• EPA Substance Registry System: 1,3-Propanediol, 1-phenyl-, 3-methanesulfonate, (S)-(115290-77-2)

Safety Data

• Hazardous Substances Data: 115290-77-2(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 33401-74-0 ethyl (3R)-3-hydroxy-3-phenylpropionate 
• 100-52-7 benzaldehyde 
• 5764-85-2 Ethyl 3-hydroxy-3-phenylpropanoate 
• 838841-85-3 (3S) ethyl β-butyryloxy-β-phenyl propionate 
• 118856-08-9 butyric acid 2-ethoxycarbonyl-1-phenyl-ethyl ester 
• 96854-34-1 (S)-3-phenyl-1,3-propanediol 
• 124-63-0 methanesulfonyl chloride 
• 98819-68-2 3-phenyl-(2R,3R)-oxiran-2-ylmethanol 

Downstream Products

• 138110-76-6 (R)-3-(4-trifluoromethylphenoxy)-3-phenylprop-1-yl methanesulfonate 
• 138110-77-7 (R)-3-Iodo-3-(4-trifluoromethylphenoxy)propane 
• 114247-06-2 (S)-fluoxetine hydrochloride 
• 114247-09-5 (R)-fluoxetine hydrochloride 
• 54910-89-3 (R)-fluoxetine 
• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 
• 82248-59-7 atomoxetine hydrochloride 
• 100568-02-3 (S)-fluoxetine 
• 105314-52-1 (R)-tomoxetine 
• 115290-79-4 (R)-3-(2-methylphenoxy)-3-phenylprop-1-yl methanesulfonate 
• 114133-36-7 (S)-(-)-3-iodo-1-phenyl-1-propanol 

Relevant articles and documents

Candida Rugosa lipase-catalyzed kinetic resolution of β-hydroxy- β-arylpropionates and δ-hydroxy-δ-aryl-β-oxo-pentanoates

A simple and convenient method was reported for the preparation of optically active β-hydroxy-β-arylpropionates, δ-hydroxy-δ- aryl-β-oxo-pentanoates and their butyryl derivatives via CRL-catalyzed hydrolysis. The optically active products are potential precursors of some chiral pharmaceuticals and natural products.

Asymmetric Synthesis of Both Enantiomers of Fluoxetine via Microbiological Reduction of Ethyl Benzoylacetate

Microbiological reduction of ethyl benzoylacetate by bakers' yeast (Saccharomyces cerevisiae), Beauveria sulfurescens or Geotrichum candidum afforded ethyl (S)-3-hydroxy-3-phenylpropionate in high optical yield.This enantiomerically pure alcohol was converted into both enantiomers of fluoxetine (7).The product resulting from the bakers' yeast reduction had ee values (87-93percent) lower than the 100percent value erroneously attributed in earlier studies.Key Words: Fluoxetine; asymmetric synthesis; bioreduction; bakers' yeast; Beauveria sulfurescens; Geotrichum candidum.

Asymmetric Synthesis of Both Enantiomers of Tomoxetine and Fluoxetine. Selective Reduction of 2,3-Epoxycinnamyl Alcohol with Red-Al.

Both enantiomers of tomoxetine 7a,7b and fluoxetine 8a,8b (as their hydrochloride salts) have been synthetized from cinnamyl alkohol by asymmetric epoxidation, and their absolute configurations have been established.Optimal conditions for regioselective Red-Al reduction at C-2 of 2,3-epoxycinnamyl alcohol are discussed.