114327-14-9

Basic information

• Product Name: 3-(4-methoxyphenyl)-3-phenylpropanoic acid
• Synonyms: AIDS134084;AIDS-134084;BIM-0013580.P001;CBMicro_013740;NSC113076;NSC631500;Oprea1_826536;STOCK1N-30158
• CAS NO: 114327-14-9
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.29644
• Mol File: 114327-14-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-methoxyphenyl)-3-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-3-phenylpropanoic acid(114327-14-9)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-3-phenylpropanoic acid(114327-14-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 114327-14-9(Hazardous Substances Data)

Usage

General Description

3-(4-methoxyphenyl)-3-phenylpropanoic acid, also known as fenoprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to reduce pain, inflammation, and fever. It works by inhibiting the production of certain substances in the body that cause pain and inflammation. Fenoprofen is often prescribed for conditions such as arthritis, menstrual cramps, and mild to moderate pain. It is typically taken orally in the form of tablets or capsules, and its effects can be felt within an hour of ingestion. However, it may cause gastrointestinal irritation and other side effects, and should be used with caution, especially in individuals with a history of stomach ulcers, liver or kidney problems, or heart disease.

Upstream product

• 140-10-3 (E)-3-phenylacrylic acid 
• 100-66-3 methoxybenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 1266101-50-1 5-((4-methoxyphenyl)(phenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 15795-54-7 5-(4-methoxybenzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 98-80-6 phenylboronic acid 
• 5720-07-0 4-methoxyphenylboronic acid 
• 621-82-9 Cinnamic acid 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 21980-07-4 (4-methoxy-benzhydryl)-malonic acid diethyl ester 
• 6768-23-6 diethyl-2-(4-methoxybenzylidene)malonate 
• 24892-80-6 2-(1-phenylvinyl)anisole 
• 855658-50-3 (4-methoxy-benzhydryl)-malonic acid 
• 17684-11-6 3-(4-anisyl)cinnamic acid 

Downstream Products

• 92247-68-2 (+/-)-2-(p-Hydroxy-phenyl)-2-phenyl-ethylamin 
• 1010458-16-8 methyl (R)-3-(4-methoxyphenyl)-3-phenylpropanoate 
• 1413936-31-8 (S)-methyl 3-(4-methoxyphenyl)-3-phenylpropanoate 
• 24736-04-7 3-Phenyl-3-(4-methoxy-phenyl)-propionsaeurechlorid 
• 76228-16-5 6-methoxy-4-phenyl-3,4-dihydroquinolin-2(1H)-one 
• 22101-03-7 3-(4-methoxyphenyl)-3-phenylpropionamide 
• 51431-54-0 2-(p-methoxyphenyl)-2-phenylethylamine 
• 53786-92-8 3-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one 

Relevant articles and documents

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Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)