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3-Chlorophenyl 4-acetylphenyl ether is an organic compound with the chemical formula C14H11ClO2. It is a derivative of phenol, where one of the hydrogen atoms on the phenyl ring is replaced by a chlorine atom, and another phenyl ring is connected through an ether linkage to the acetyl group. 3-chlorophenyl 4-acetylphenyl ether is characterized by its molecular structure, which consists of two aromatic rings, one with a chlorine substituent and the other with an acetyl group. It is a colorless to pale yellow solid and is used in various chemical reactions and as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The compound's properties, such as its reactivity and solubility, are influenced by the presence of the chlorine and acetyl groups, making it a versatile building block in organic synthesis.

1145-57-9

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1145-57-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1145-57-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,4 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1145-57:
(6*1)+(5*1)+(4*4)+(3*5)+(2*5)+(1*7)=59
59 % 10 = 9
So 1145-57-9 is a valid CAS Registry Number.

1145-57-9Relevant academic research and scientific papers

SUBSTITUTED 4-ARYLOXY AND 4-ARYLSULFANYL-PHENYL-2-AMINOTHIAZOLES AS INHIBITORS OF CELL PROLIFERATION

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Page/Page column 30-33, (2008/06/13)

The invention discloses compounds which are substituted 4-aryloxy and 4-arylsulfanyl-phenyl-2-aminothiazoles with anti-cancer activity. The invention futher discloses methods of preparing compounds of the invention. The invention also discloses methods of inhibiting cell proliferation and tumor growth in a subject by administering compounds of the invention to the subject.

Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl- phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation

Gorczynski, Michael J.,Leal, Rachel M.,Mooberry, Susan L.,Bushweller, John H.,Brown, Milton L.

, p. 1029 - 1036 (2007/10/03)

Several substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles were synthesized and evaluated for cytotoxic activity against estrogen-positive, estrogen-negative, and adriamycin-resistant human breast cancer cell lines. 4-[4′-(3,4-Dichlorophenoxy)-phenyl]-thiazol-2-yl ammonium iodide demonstrated potent activity against both estrogen-positive and negative breast cancer cell lines with low micromolar (μM) GI50 values. In addition, we have identified several 2-aminothiazoles that demonstrated selective potency for the adriamycin-resistant and estrogen-negative breast cancer cell lines. The results suggest that these 2-aminothiazoles represent lead compounds for evaluation in animal models of breast cancer.

SYNTHESIS AND REACTIVITY OF ARYLOXYCUMENYL CHLORIDES

Litvinenko, L. M.,Benndorf, V.,Popova, R. S.,Popov, A. F.,Tormosin, I. I.

, p. 680 - 683 (2007/10/02)

A series of derivatives of aryloxycumenyl chlorides containing substituents (methyl, methoxy, fluorine, and chlorine) at positions 3 and 4 of the aryl ring were synthesized.From the results from their solvolysis in 90 vol. percent aqueous acetone it was concluded that there is strong transfer of the electronic effects through the diphenyl ether system comparable with that in biphenyl.

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