114932-60-4Relevant academic research and scientific papers
Noncovalent immobilization of Co(ii)porphyrin through axial coordination as an enhanced electrocatalyst on carbon electrodes for oxygen reduction and evolution
Attatsi, Isaac Kwaku,Zhu, Weihua,Liang, Xu
, p. 4340 - 4345 (2020)
Catalysis of fuel-producing reactions can be transferred from homogeneous solution to a surface via attachment of the molecular catalyst. A pyrene-pyridine hybrid (Py-Py) was used as an axial ligand to bridge Co(ii)tetraphenylporphyrin which was finally immobilized on carbon nanotubes via noncovalent interactions and further deposited on glassy carbon. This noncovalent immobilization of Co(ii)porphyrin through axial coordination provides significantly enhanced electrochemically catalyzed oxygen reduction and oxygen evolution, illustrating a new insight into understanding surface catalysis.
Highly efficient oxidation of water by a molecular catalyst immobilized on carbon nanotubes
Li, Fei,Zhang, Biaobiao,Li, Xiaona,Jiang, Yi,Chen, Lin,Li, Yanqing,Sun, Licheng
, p. 12276 - 12279 (2011)
A successful team: A molecular device based on multiwalled carbon nanotubes functionalized by a mononuclear ruthenium catalyst has been shown to split water electrochemically (see picture; ITO=indium tin oxide). The readily prepared electrode showed excellent electrocatalytic activity for the oxidation of water, a high current density, and a low overpotential, and constitutes one step forward in the design of artificial photosynthetic systems.
A nanoscale graphene oxide-peptide biosensor for real-time specific biomarker detection on the cell surface
Wang, Zhe,Huang, Peng,Bhirde, Ashwinkumar,Jin, Albert,Ma, Ying,Niu, Gang,Neamati, Nouri,Chen, Xiaoyuan
, p. 9768 - 9770 (2012)
A nanoscale RGD-pyrene-graphene oxide (GO) biosensor was prepared for real-time in situ detection of a cancer cell surface marker, integrin αvβ3. This nanoscale GO-based biosensor is simple, robust, sensitive and of high selectivity. It can also be adapted to other cancer cell surface marker evaluation systems. The Royal Society of Chemistry 2012.
Interface molecular engineering of single-walled carbon nanotube/epoxy composites
Yan, Yehai,Cui, Jian,Zhao, Shuai,Zhang, Jinfang,Liu, Jiwen,Cheng, Junmei
, p. 1928 - 1936 (2012)
Dispersion of large single-walled carbon nanotube (SWCNT) bundles into individual nanotubes or small bundles and thus strengthening of the nanotube/matrix interfacial interaction are prerequisites for taking full advantage of the remarkable multifunctional properties of SWCNTs in various carbon nanotube-based composites. Noncovalent functionalization of SWCNTs is an attractive option to simultaneously achieve these conditions. Toward this end, three reactive amino-containing pyrene derivatives (AmPys) with various spacer chain lengths were synthesized. One with the longest spacer length (12 methylene units, AmPy-12) shows the highest functionalization efficiency for SWCNTs in terms of dispersibility. Systematic characterization on a SWCNT/AmPy-12 hybrid suggests that ca. 10 wt% of AmPy-12 is strongly adsorbed on SWCNTs through π-π interactions, making them steadily dispersed into individual ones and/or small bundles without noticeable change in their electronic structure. AmPy-12-functionalized SWCNTs were then used for the preparation of epoxy composites. Since the SWCNT/epoxy interface was well engineered at a molecular level by application of AmPy-12, which interacts noncovalently with SWCNT but bonds chemically to the epoxy matrix, the composite with only 0.3 wt% SWCNTs displays an increase of 54% and 27% in tensile strength and Young's modulus, respectively, over neat resin. A low electrical percolation threshold of 0.1 wt% SWCNTs and improved thermal properties were also observed.
Oligonucleotide-polyamide hybrid molecules containing multiple pyrene residues exhibit significant excimer fluorescence
Tong, Glenn,Lawlor, John M.,Tregear, Geoffrey W.,Haralambidis, Jim
, p. 12151 - 12158 (1995)
Oligonucleotide-polyamide hybrid molecules bearing multiple pyrene residues in the polyamide moiety were prepared. These molecules were designed to promote pyrene excimer formation and avoid intercalation of the label into the DNA duplex. Significant excimer fluorescence was observed, and this was shown to increase with the number of pyrene residues present. Hence, there is potential for further increasing of the fluorescence intensity by incorporation of additional label residues. Excimer fluorescence intensity was also shown to be sensitive to duplex formation. Fluorescence measurements and melting temperature studies gave no evidence of intercalation of the pyrene residues into duplex DNA. The hybridization properties of these hybrid molecules are similar to those of unmodified oligonucleotides. It seems, then, likely that pyrenylated oligonucleotide-polyamide hybrids may be useful as oligonucleotide probes.
Nucleic acid chemistry in the organic phase: From functionalized oligonucleotides to dna side chain polymers
Liu, Kai,Zheng, Lifei,Liu, Qing,De Vries, Jan Willem,Gerasimov, Jennifer Y.,Herrmann, Andreas
, p. 14255 - 14262 (2014)
DNA-incorporating hydrophobic moieties can be synthesized by either solid-phase or solution-phase coupling. On a solid support the DNA is protected, and hydrophobic units are usually attached employing phosphoramidite chemistry involving a DNA synthesizer. On the other hand, solution coupling in aqueous medium results in low yields due to the solvent incompatibility of DNA and hydrophobic compounds. Hence, the development of a general coupling method for producing amphiphilic DNA conjugates with high yield in solution remains a major challenge. Here, we report an organic-phase coupling strategy for nucleic acid modification and polymerization by introducing a hydrophobic DNA-surfactant complex as a reactive scaffold. A remarkable range of amphiphile-DNA structures (DNA-pyrene, DNA-triphenylphosphine, DNA-hydrocarbon, and DNA block copolymers) and a series of new brush-type DNA side-chain homopolymers with high DNA grafting density are produced efficiently. We believe that this method is an important breakthrough in developing a generalized approach to synthesizing functional DNA molecules for self-assembly and related technological applications.
Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker
Yeh, Nai-Hua,Krueger, Ruby,Moeller, Kevin D.
, p. 5440 - 5444 (2021)
Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.
Surface molecular engineering of axial-exchanged Fe(III)Cl- and Mn(III)Cl-porphyrins towards enhanced electrocatalytic ORRs and OERs
Attatsi, Isaac Kwaku,Zhu, Weihua,Liang, Xu
, (2020)
Herein, pyrene-pyridine (Pyr-Py) molecule was applied as the axial exchanged ligand to bridge Fe(III) and Mn(III)porphyrin immobilized on rGO. These axially exchanged metalloporphyrin functionalized nanocomposites revealed enhanced electrochemically catal
Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates
Story, Sandra,Skriba, Michael J.,Maiti, Krishnagopal,Nihar Ranjan,Degtyareva, Natalya N.,Green, Keith D.,Khodaverdian, Verjine,Oyelere, Adegboyega K.,Garneau-Tsodikova, Sylvie,Arya, Dev P.
, p. 381 - 393 (2019)
The development of new ligands that have comparable or enhanced therapeutic efficacy relative to current drugs is vital to the health of the global community in the short and long term. One strategy to accomplish this goal is to functionalize sites on cur
Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis
Sadlowski, Corinne,Balderston, Sarah,Sandhu, Mandeep,Hajian, Reza,Liu, Chao,Tran, Thanhtra P.,Conboy, Michael J.,Paredes, Jacobo,Murthy, Niren,Conboy, Irina M.,Aran, Kiana
, p. 3230 - 3238 (2018)
Studies of heterochronic parabiosis, where two animals of different ages are joined surgically, provided proof-of-principle results that systemic proteins have broad age-specific effects on tissue health and repair. In an effort to identify these systemic proteins, we previously developed a method to selectively label the proteome of only one animal joined in parabiosis utilizing bio-orthogonal non-canonical amino acid tagging (BONCAT), which can metabolically label proteins during their de novo synthesis by incorporating a methionine substitute, azido-nor-leucine (ANL), in cells expressing a mutant methionyl-tRNA synthetase (MetRSL274G). Once labeled, we can selectively identify the proteins produced by the MetRSL274G transgenic mouse in the setting of heterochronic parabiosis. This approach enabled the detection of several rejuvenating protein candidates from the young parabiont, which were transferred to the old mammalian tissue through their shared circulation. Although BONCAT is a very powerful technology, the challenges associated with its complexity including large starting material requirements and cost of ANL-labeled protein detection, such as modified antibody arrays and mass spectrometry, limit its application. Herein, we propose a lab-on-a-chip technology, termed Click-A+Chip for facile and rapid digital detection of ANL-labeled proteomes present in minute amount of sample, to replace conventional assays. Click-A+Chip is a graphene-based field effect biosensor (gFEB) which utilizes novel on-chip click-chemistry to specifically bind to ANL-labeled biomolecules. In this study, Click-A+Chip is utilized for the capture of ANL-labeled proteins transferred from young to old parabiotic mouse partners. Moreover, we were able to identify the young-derived ANL-labeled Lif-1 and leptin in parabiotic systemic milieu, confirming previous data as well as providing novel findings on the relative levels of these factors in young versus old parabionts. Summarily, our results demonstrate that Click-A+Chip can be used for rapid detection and identification of ANL-labeled proteins, significantly reducing the sample size, complexity, cost and time associated with BONCAT analysis.
