115220-67-2Relevant articles and documents
Design and Synthesis of &γ-Oxygenated Phosphinothricins as Inhibitors of Glutamine Synthetase
Walker, Daniel M.,McDonald, John F.,Franz, John E.,Logusch, Eugene W.
, p. 659 - 666 (2007/10/02)
The ability of L-γ-hydroxyglutamic acids to act as substrates of the enzyme glutamine synthetase (GS) was exploited as a rationale for the synthesis of γ-oxygenated analogues of the naturally occurring GS inhibitor phosphinothricin (PPT).The potent new in
Synthesis of D,L-&γ-Hydroxyphosphinothricin, a Potent New Inhibitor of Glutamine Synthetase
Walker, Daniel M.,McDonald, John F.,Logusch, Eugene W.
, p. 1710 - 1711 (2007/10/02)
A flexible synthesis of D,L-γ-hydroxyphosphothricin (GHPPT), a potent inhibitor of the enzyme glutamine synthetase, is described which features silicon-mediated addition of ethyl methylphosphinate to benzyl 2-benzyloxycarbonylamino-4-oxobutyrate; selectiv
