58641-56-8

Upstream product

• 100-39-0 benzyl bromide 
• 75626-75-4 sodium 2-<<(benzyloxy)carbonyl>amino>-4-hydroxybutanoate 
• 4515-20-2 Z-Asp-OBn 
• 126400-99-5 C₂₀H₂₃NO₄ 
• 501-53-1 benzyl chloroformate 
• 31332-88-4 (S)-3-(N-benzyloxycarbonylamino)tetrahydrofuran-2-one 
• 58611-62-4 benzyl DL-N-(benzyloxycarbonyl)homoserinate 

Downstream Products

• 75626-70-9 methyl 4-<<4-oxo-4-(benzyloxy)-3-<amino>butyl>amino>-α-oxophenylacetate dimethyl ketal 
• 420847-91-2 Benzyl (2RS)-2-Benzyloxycarbonylamino-4-benzylthio-4-benzylsulfinylbutanoate 
• 1363373-25-4 C₁₉H₂₀N₂O₅ 
• 1363373-26-5 C₁₂H₁₄N₂O₄ 
• 115220-77-4 benzyl DL-O-acetyl-N-benzyloxocarbonyl-4-homoserinate 
• 115220-67-2 benzyl DL-N-benzyloxycarbonyl-4-homoserinate 
• 128984-21-4 benzyl DL-5--2-oxotetrahydrofuran-3-ylcarbamate 
• 420847-90-1 Benzyl(2RS)-2-Benzyloxycarbonylamino-4,4-dibenzylthiobutanoate 
• 115220-66-1 benzyl DL-N-benzyloxycarbonyl-4--O-trimethylsilylhomoserinate 

Relevant academic research and scientific papers

PROTECTED DERIVATIVES OF 2-AMINO-4-PHOSPHOBUTANOIC ACID

Provided herein are phosphonate compounds useful for the manufacture of serine phosphopeptide mimetics.

ETHYNYLBENZENE DERIVATIVES

Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

Beta-strand mimetics and method relating thereto

Conformationally constrained compounds which mimic the secondary structure of β-strand regions of biologically active peptides and proteins are disclosed. Such β-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the β-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.

BETA-STRAND MIMETICS AND METHOD RELATING THERETO

Conformationally constrained compounds which mimic the secondary structure of ?-strand regions of biologically active peptides and proteins are disclosed. Such ?-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the ?-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.

Design and Synthesis of &γ-Oxygenated Phosphinothricins as Inhibitors of Glutamine Synthetase

The ability of L-γ-hydroxyglutamic acids to act as substrates of the enzyme glutamine synthetase (GS) was exploited as a rationale for the synthesis of γ-oxygenated analogues of the naturally occurring GS inhibitor phosphinothricin (PPT).The potent new in

Synthesis of D,L-&γ-Hydroxyphosphinothricin, a Potent New Inhibitor of Glutamine Synthetase

A flexible synthesis of D,L-γ-hydroxyphosphothricin (GHPPT), a potent inhibitor of the enzyme glutamine synthetase, is described which features silicon-mediated addition of ethyl methylphosphinate to benzyl 2-benzyloxycarbonylamino-4-oxobutyrate; selectiv

Synthesis of (Z)-4-(acylamino)- and 4-(alkylamino)-α-oximinophenylacetic acids: properties and stereochemical determination

The preparation, properties, and stereochemical determinations of a series of 4-substituted α-oximinophenylacetic acids are described.The 4-acetamino and 4-amino>-α-oxophenylacetic acids 7 and 19 were synthesized from the corresponding acetophenones with selenium dioxide.The oximes were then prepared and their stereochemistry determined as Z (syn), through the chemical properties of the methoxyimino derivatives.A key intermediate was (Z)-methyl 4-amino>-α-imino>phenylacetate (24), which was synthesized from the free oxime or from the keto acid by using O-(tetrahydropyran-2-yl)hydroxylamine.Deprotection of this compound at nitrogen gave the 4-amino-α-oximino ester, 25, which was acylated with a variety of acid chlorides and hydrolyzed to the 4-(acylamino)-α-oximinophenylacetic acids.By employment of methyl 4-amino-α-oxophenylacetate dimethyl ketal (9), a general reductive amination process was developed, leading to the 4-(alkylamino)-α-oximinophenylacetic acids.

Analogues of S adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5' thioether linkage

The synthesis of S adenosylhomocysteine analogues, in which the 5' thioether linkage is replaced by an oxygen or nitrogen isostere, has been investigated. These compounds were designed to be resistant to enzyme catalyzed hydrolytic cleavage of the 5' subs