1165-64-6

Usage

Chemical Structure

A triazole ring with a 4-chlorophenyl group at the 5th position and two phenyl groups at the 1st and 3rd positions.

Molecular Weight

307.77 g/mol

Functional Groups

Triazole ring, phenyl groups, and a chlorine atom

Physical State

Likely a solid at room temperature (based on molecular weight and structure)

Applications

a. Building block in pharmaceuticals and agrochemicals synthesis
b. Studied for antifungal properties
c. Studied for antimicrobial properties
d. Studied for antitumor properties
e. Investigated for use in new materials development
f. Potential use as a ligand in coordination chemistry

Solubility

Solubility information not provided, but likely soluble in organic solvents due to the presence of phenyl groups

Stability

Stability information not provided, but the compound may be sensitive to light, heat, or moisture due to the presence of the triazole ring and phenyl groups

Reactivity

Reactivity information not provided, but the compound may react with strong acids, strong bases, or nucleophiles due to the presence of the triazole ring and phenyl groups

Hazards

Hazard information not provided, but the compound may be hazardous due to its potential use in pharmaceuticals and agrochemicals, and the presence of a chlorine atom

Storage

Storage conditions not provided, but it should be stored in a cool, dry, and dark place, away from heat, light, and moisture to maintain stability

Regulatory Status

Regulatory information not provided, but the compound may be subject to regulations depending on its intended use and concentration in products

Environmental Impact

Environmental impact information not provided, but the compound may have an impact on the environment due to its potential use in pharmaceuticals and agrochemicals, and the presence of a chlorine atom

Upstream product

• 18039-45-7 2,5-diphenyl-2H-tetrazole 
• 142312-03-6 2-(4-Chloro-phenyl)-4-p-tolyl-2H-oxazol-5-one 
• 825-60-5 benzimidic acid ethyl ester 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 
• 104-86-9 4-chlorobenzylamine 
• 588-64-7 (E)-1-benzylidene-2-phenylhydrazine 
• 104-88-1 4-chlorobenzaldehyde 
• 588-64-7 benzaldehyde phenylhydrazone 
• 87436-46-2 4-Chloro-N-[1-ethoxy-1-phenyl-meth-(Z)-ylidene]-benzamide 
• 52810-03-4 4-Chloro-N-thiobenzoyl-benzamide 
• 59-88-1 phenylhydrazine hydrochloride 
• 34924-43-1 1,3-diphenyl-1,2,4-triazole 
• 623-03-0 4-Cyanochlorobenzene 

Relevant academic research and scientific papers

An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds

An electro-oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported. This strategy successfully prepared a series of 1,2,4-triazoles in satisfact

An electrochemical multicomponent [3 + 1 + 1] annulations to synthesize polysubstituted 1,2,4-triazoles

An electrochemical multicomponent [3 + 1 + 1] annulation used for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed under transition-metal-, acid-, base- and external-oxidant-free conditions. In an undivided cell, a variety of hydrazones and aldehydes smoothly participate in this transformation to furnish a range of substituted 1,2,4-triazoles. The reaction constitutes a new transformation from hydrazones, aldehydes and NH4OAc into 1,2,4-triazoles, providing a unifying, simple and environmentally friendly approach to the currently available methods.

TBHP/TBAI–Mediated simple and efficient synthesis of 3,5-disubstituted and 1,3,5-trisubstituted 1H-1,2,4-triazoles via oxidative decarbonylation of aromatic aldehydes and testing for antibacterial activities

The author has developed a simple, efficient and eco–friendly convenient general method for synthesis of 3,5–disubstituted–1,2,4–triazoles and 1,3,5–trisubstituted–1,2,4–triazoles from 3–monosubstituted–1,2,4–triazoles and 1,3–disubstituted–1,2,4–triazoles respectively using tetrabutylammonium iodide (TBAI) as catalyst and TBHP as oxidant under mid reaction conditions. This method provides structurally diverse 3,5–disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles in good to excellent yields. 3,5–Disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles derivatives are biologically and pharmaceutically active molecules, and therefore, this protocol could be of wide applications in medicinal chemistry and organic chemistry.

Direct Access to 1,3,5-Trisubstituted 1 H -1,2,4-Triazoles from N -Phenylbenzamidines via Copper-Catalyzed Diamination of Aryl Nitriles

A copper-catalyzed formation of C-N/N-N bonds using N-phenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environme

OXAZOLONES. PART VI. REACTION OF 5(4H)-OXAZOLONES WITH NITRILE IMINES: SYNTHESIS OF 1H-1,2,4-TRIAZOLES THROUGH CYCLOADDITION

5(4H)-Oxazolones (1) react as dipolarophiles in cycloadditions with nitrile imines generated from tetrazoles (2) in refluxing anisole affording two 1H-1,2,4-triazole derivatives (3) and diarylethylenes (4).

Synthesis of 1,2,4-Triazoles and 1,2,4-Oxadiazoles

Monothiodiacylamines reacted regiospecifically with hydrazines and hydroxylamine to give substituted 1,2,4-triazoles and 1,2,4-oxadiazoles in excellent yields.