116530-25-7

Usage

General Description

2-Amino-7-methylnaphthalene, also known as 7-Methyl-2-aminonaphthalene, is a chemical compound with a molecular formula C11H11N. It is a derivative of naphthalene, with a methyl group attached to the 7th carbon and an amino group attached to the 2nd carbon. 2-Amino-7-methylnaphthalene is commonly used as a raw material for the synthesis of dyes, pigments, and other organic compounds. It is also known for its potential health effects, as it is classified as a possible human carcinogen by the National Toxicology Program. Additionally, 2-Amino-7-methylnaphthalene is classified as a hazardous substance, and exposure to this chemical should be limited and carefully controlled.

Upstream product

• 91137-28-9 2-methyl-7-nitronaphthalene 
• 6939-38-4 N-(7-methyl-[1]naphthyl)-acetamide 
• 859070-26-1 7-methyl-2-nitro-[1]naphthylamine 
• 26593-50-0 7-methylnaphthalen-2-ol 
• 116230-30-9 7-bromonaphthalen-2-ol 
• 676-58-4 methylmagnesium chloride 
• 860746-24-3 N-(7-methyl-2-nitro-[1]naphthyl)-acetamide 
• 64-19-7 acetic acid 

Relevant academic research and scientific papers

Method for resolving chiral compound

The invention relates to the field of organic chemistry, in particular to a method for resolving a chiral compound. The method for splitting the chiral compound provided by the invention comprises thestep of carrying out addition reaction on a racemic compound shown as a formula A and azodicarbonic acid ester in the presence of a catalyst so as to provide an S-configuration compound shown as theformula A and an S-configuration compound shown as the formula C. According to the method, chiral phosphoric acid is used as a catalyst; good catalytic effect is achieved, and very wide substrate applicability is also achieved; the product and the recovered raw material can be obtained with excellent enantioselectivity, the selectivity coefficient of kinetic resolution can reach 371, and the method has an excellent kinetic resolution effect on various N-monosubstituted and N-unsubstituted binaphthalene diamines, H8-binaphthalene diamines and biphenyl diamines.

A Versatile Method for Kinetic Resolution of Protecting-Group-Free BINAMs and NOBINs through Chiral Phosphoric Acid Catalyzed Triazane Formation

A versatile kinetic resolution of protecting-group-free BINAMs and NOBINs has been realized through chiral phosphoric acid catalyzed triazane formation with azodicarboxylates. A series of mono-N-protected and unprotected BINAMs, diphenyl diamines and NOBIN derivatives could be kinetically resolved with excellent performances (with s factor up to 420). The gram-scale reactions and facile derivatizations of the chiral products demonstrate the potential of these methods in the asymmetric synthesis of chiral catalysts and ligands.

Organocatalytic Atroposelective Arylation of 2-Naphthylamines as a Practical Approach to Axially Chiral Biaryl Amino Alcohols

The first phosphoric acid catalyzed direct arylation of 2-naphthylamines with iminoquinones for the atroposelective synthesis of axially chiral biaryl amino alcohols has been developed. This reaction constitutes a highly functional-group-tolerant route for the rapid construction of enantioenriched axially chiral biaryl amino alcohols, and is a rare example of 2-naphthylamines acting as nucleophiles in an organocatalytic enantioselective transformation. Furthermore, the products, which feature various halogen atoms, provide access to structurally diverse axially chiral amino alcohols through further transformations.