1166870-22-9Relevant academic research and scientific papers
2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses
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Page/Page column 21, (2012/11/13)
This invention discloses 2α-methyl and 2β-methyl analogs of 19,26-dinor-1α,25-dihydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit in vitro biological activities evidencing use as an anti-cancer agent and for the treatm
Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription
Grzywacz, Pawel,Chiellini, Grazia,Plum, Lori A.,Clagett-Dame, Margaret,Deluca, Hector F.
experimental part, p. 8642 - 8649 (2011/03/20)
Twelve new analogues of 19-nor-1α,25-dihydroxyvitamin D3 (5-16) were prepared by convergent syntheses, employing the Wittig Horner reaction. The necessary Grundmann type ketones (45-48), possessing fixed configurations of the hydroxyl group at
2-Methylene-(20S,25S)-19,26-Dinor-Vitamin D Analogs
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Page/Page column 6; 8, (2009/07/17)
This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arrestin
