116707-97-2

Upstream product

• 32338-02-6 2-bromo-4-methoxyaniline 
• 79-10-7 acrylic acid 
• 814-68-6 acryloyl chloride 
• 98447-30-4 2-bromo-4-methoxy-1-nitrobenzene 
• 5470-65-5 3-bromo-4-nitrophenol 
• 591-20-8 3-Bromophenol 

Downstream Products

• 444166-96-5 N-(2-bromo-4-methoxyphenyl)-N-(2-trimethylsilylethoxymethyl)acrylamide 
• 116707-99-4 1,3-dimethyl-5-methoxyindolin-2-one 
• 324520-90-3 3-[(2-bromo-4-methoxy-phenyl)-(2-trimethylsilanyl-ethoxymethyl)-carbamoyl]-pyrrole-1-carboxylic acid methyl ester 
• 324520-82-3 1H-pyrrole-3-carboxylic acid (2-bromo-4-methoxy-phenyl)-(2-trimethylsilanyl-ethoxymethyl)-amide 
• 324520-93-6 1-methyl-1H-pyrrole-3-carboxylic acid (2-bromo-4-methoxy-phenyl)-(2-trimethylsilanyl-ethoxymethyl)-amide 
• 324520-87-8 3-[(2-bromo-4-methoxy-phenyl)-methyl-carbamoyl]-pyrrole-1-carboxylic acid tert-butyl ester 
• 324520-81-2 N-(2-bromo-4-methoxyphenyl)-N-methyl-1H-3-pyrrolecarboxamide 
• 116707-98-3 N-(2-bromo-4-methoxyphenyl)-N-methylacrylamide 
• 7766-37-2 N-(4-methoxyphenyl)acrylamide 

Relevant academic research and scientific papers

Rh-Catalyzed Domino Addition-Enolate Arylation: Generation of 3-Substituted Oxindoles via a Rh(lll) Intermediate

A Rh-catalyzed domino conjugate addition-arylation sequence via a Rh(III) intermediate is reported. This process involving a proposed intramolecular oxidative addition of a rhodium enolate was utilized to achieve the synthesis of 3-substituted oxindole derivatives in moderate to excellent yields.

Aryl radical cyclisation onto pyrroles

The intramolecular cyclisation of aryl radicals onto a pyrrole is studied. The cyclisation allows the synthesis of either the spiropyrrolidinyloxindole or the pyrrolo[3,2-c]quinoline skeleton depending on the nature of the protecting group at the N-pyrrole atom. The regiochemistry of the cyclisation is not affected by the substituents on the benzene ring. Some limitations on the utility of tosylmethylisocyanide in pyrrole synthesis are also reported.

Indirect Electroreductive Cyclisation of N-Allylic and N-Propargylbromo Amides and o-Bromoacryloylanilides using Nickel(II) Complexes as Electron-transfer Catalysts

Nickel(II) complex-catalysed indirect electroreduction of N-allylic and N-propargyl-α-bromo amides and o-bromoacryloylanilides gave the corresponding 5-membered lactams.The product distribution was affected by the ability of the solvent to donate hydrogen atom.The electroreduction of N-allyl-N-(bromoacetyl)toluene-p-sulfonamide 1a in DMF and acetonitrile yielded as main product the 4-methylpyrrolidinone 2a (41percent) and the 4-(bromomethyl)pyrrolidinone 3a (33percent), respectively.On addition of 2 mol equiv. of a hydrogen-atom donor (Ph2PH) to the reaction of bromo amide 1a in acetonitrile, compound 1a provided compound 2a (58percent) as the sole cylised product.