118067-91-7

Upstream product

• 67-56-1 methanol 
• 75-44-5 phosgene 
• 123539-23-1 (5R,7R,8R)-7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-8-ol 
• 118097-87-3 (5R,7R,8R)-7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-8-ol; hydrochloride 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 124803-96-9 (+/-)-4-(3,4-methylenedioxybenzyl)-1,3-oxazolidin-2-one 
• 607742-47-2 (-)-(S)-3,4-methylenedioxyphenylalaninol 
• 37002-51-0 (R)-2-amino-3-<3,4-(methylenedioxy)phenyl>propionic acid 
• 147922-33-6 (-)-(S)-4-(3,4-methylenedioxybenzyl)-1,3-oxazolidin-2-one 
• 120-57-0 piperonal 
• 59276-37-8 3,4,5-trimethoxybenzaldehyde dimethyl acetal 
• 58908-02-4 3,4,5-trimethoxyphenilidinbenzenesulfonimide 
• 127951-17-1 ((4S,5S)-5-Benzo[1,3]dioxol-5-yl-4,5-dihydro-oxazol-4-yl)-methanol 
• 123474-70-4 2-Bromo-1-(6-bromo-benzo[1,3]dioxol-5-yl)-propane-1,3-diol 

Downstream Products

• 123474-73-7 4-keto-2-azapodophyllotoxin 
• 118067-91-7 (+/-)-2-azapodophyllotoxin 

Relevant academic research and scientific papers

Design, synthesis, and antitumor activity-absolute configuration relationships of podophyllotoxin aza-analogues

Optically active and racemic podophyllotoxin aza-analogues 3-7 were designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 10 or 16 with 3,4,5-trimethoxybenzaldehyde 11 and were found to show a promising in vitro a

THE SYNTHESIS OF 2-AZAPODOPHYLLOTOXINS

2-Azapodophyllotoxins, tetrahydroisoquinoline-analogues of podophyllotoxin have been synthesized.They constitute a new class of highly potent anti-tumor agents.