118092-39-0Relevant academic research and scientific papers
SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE DELTA INHIBITOR AND USE THEREOF
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, (2018/02/03)
The present invention belongs to the field of medicinal chemistry, and relates to substituted pyrimidine compounds as phosphatidylinositol 3-kinase (PI3K) δ inhibitor and a use thereof. In particular, the present invention provides a compound as shown by formula I or an isomer, pharmaceutically acceptable salt, solvate or prodrug thereof, the preparation methods of same and pharmaceutical compositions containing these compounds and a use of these compounds or compositions for treating cancer, hyperblastosis diseases or inflammatory diseases. The compounds of the present invention have a good inhibiting activity on PI3Kδ and have a high selectivity. It is hoped that these will be therapeutic agents for cancer, hyperblastosis diseases or inflammatory diseases.
One-pot synthesis of 3-methylflavones and their transformation into (E)-3-styrylflavones via Wittig reactions
Rocha, Djenisa H. A.,Pinto, Diana C. G. A.,Silva, Artur M. S.
, p. 2683 - 2686 (2014/01/06)
An efficient one-pot synthesis of 3-methylflavone derivatives is established. Furthermore, their transformation into phosphorus ylides, which are then used in the diastereoselective synthesis of (E)-styrylflavones through Wittig reactions, is also studied
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme
Gobbi, Silvia,Cavalli, Andrea,Rampa, Angela,Belluti, Federica,Piazzi, Lorna,Paluszcak, Anja,Hartmann, Rolf W.,Recanatini, Maurizio,Bisi, Alessandra
, p. 4777 - 4780 (2007/10/03)
Following our SAR studies on aromatase inhibitors, new compounds were designed by appropriately modifying the structure of flavone 1 using our previously reported CoMFA model. While the introduction of substituents on the 2-phenyl ring alone did not cause
Unsymmetrical Bichromonyl Benzene Derivatives from Formyl Flavones
Wurm, Gotthard,Nordmann, Matthias
, p. 555 - 558 (2007/10/02)
New flavones (4b-f/6) with formyl functions in the 3-, 4'-, 6- and 4',6-positions are synthesized from bromomethyl or dibromomethyl flavone derivatives (3a-e) with methylflavones (2a-e) as starting compounds.The formyl flavones are suitable synthetic tool
