29220-20-0Relevant academic research and scientific papers
SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE DELTA INHIBITOR AND USE THEREOF
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, (2018/02/03)
The present invention belongs to the field of medicinal chemistry, and relates to substituted pyrimidine compounds as phosphatidylinositol 3-kinase (PI3K) δ inhibitor and a use thereof. In particular, the present invention provides a compound as shown by formula I or an isomer, pharmaceutically acceptable salt, solvate or prodrug thereof, the preparation methods of same and pharmaceutical compositions containing these compounds and a use of these compounds or compositions for treating cancer, hyperblastosis diseases or inflammatory diseases. The compounds of the present invention have a good inhibiting activity on PI3Kδ and have a high selectivity. It is hoped that these will be therapeutic agents for cancer, hyperblastosis diseases or inflammatory diseases.
Unsymmetrical Bichromonyl Benzene Derivatives from Formyl Flavones
Wurm, Gotthard,Nordmann, Matthias
, p. 555 - 558 (2007/10/02)
New flavones (4b-f/6) with formyl functions in the 3-, 4'-, 6- and 4',6-positions are synthesized from bromomethyl or dibromomethyl flavone derivatives (3a-e) with methylflavones (2a-e) as starting compounds.The formyl flavones are suitable synthetic tool
Synthesis of 3-(substituted methyl)-2-phenyl-4H-1-benzothiopyran-4-ones
Nakazumi,Ueyama,Sonoda,Kitao
, p. 2323 - 2324 (2007/10/02)
Reaction of 2-phenyl-4H-1-benzothiopyran-4-ones and related compounds with chloromethyl methyl ether and fuming sulfuric acid gave mainly the 3-chloromethyl compound, whereas chloromethylation of methoxy-substituted thioflavones took place at another position or gave the tris(chloromethyl) compound. 3-(Chloromethyl)thioflavone could be easily converted into various 3-(substituted methyl)thioflavones which showed significant antimicrobial activity against Trichophytons.
