1184174-04-6

Basic information

• Product Name: 3-(4-Bromophenyl)-1-Methyl-1H-1,2,4-Triazole
• Synonyms: 3-(4-Bromophenyl)-1-Methyl-1H-1,2,4-Triazole
• CAS NO: 1184174-04-6
• Molecular Formula: C₉H₈BrN₃
• Molecular Weight: 238.08392
• Mol File: 1184174-04-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 361.6±44.0 °C(Predicted)
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• PKA: 2.38±0.10(Predicted)
• CAS DataBase Reference: 3-(4-Bromophenyl)-1-Methyl-1H-1,2,4-Triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Bromophenyl)-1-Methyl-1H-1,2,4-Triazole(1184174-04-6)
• EPA Substance Registry System: 3-(4-Bromophenyl)-1-Methyl-1H-1,2,4-Triazole(1184174-04-6)

Safety Data

• Hazardous Substances Data: 1184174-04-6(Hazardous Substances Data)

Usage

General Description

3-(4-Bromophenyl)-1-Methyl-1H-1,2,4-Triazole is a chemical compound with the molecular formula C9H8BrN3. It is a triazole derivative with a bromophenyl group and a methyl group attached to the triazole ring. 3-(4-Bromophenyl)-1-Methyl-1H-1,2,4-Triazole is often used in pharmaceutical research and drug development due to its potential as a pharmacological agent. It exhibits a range of biological activities, including antifungal, anticancer, and antiviral properties. The specific chemical structure and properties of 3-(4-Bromophenyl)-1-Methyl-1H-1,2,4-Triazole make it valuable for further exploration in medical and scientific applications.

Upstream product

• 64-18-6 formic acid 
• 1184296-78-3 4-bromo-N'-methylbenzimidohydrazide 
• 55368-83-7 4-bromo-benzimidic acid ethyl ester hydrochloride 
• 623-00-7 4-bromobenzenecarbonitrile 
• 55368-42-8 4-bromobenzamidine hydrochloride 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1184174-05-7 4-[4-(1-methyl-1H-[1,2,4]triazol-3-yl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1282473-31-7 C₁₇H₂₂N₄O₂ 
• 1184174-06-8 2-chloro-1-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)ethan-1-one 
• 1184173-73-6 (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide 

Relevant articles and documents

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology

The emergence and evolution of new immunological cancer therapies has sparked a rapidly growing interest in discovering novel pathways to treat cancer. Toward this aim, a novel series of pyrrolidine derivatives (compound 5) were identified as potent inhibitors of ERK1/2 with excellent kinase selectivity and dual mechanism of action but suffered from poor pharmacokinetics (PK). The challenge of PK was overcome by the discovery of a novel 3(S)-thiomethyl pyrrolidine analog 7. Lead optimization through focused structure-activity relationship led to the discovery of a clinical candidate MK-8353 suitable for twice daily oral dosing as a potential new cancer therapeutic.

Copper-Catalyzed Oxidative C(sp3)-H Functionalization for Facile Synthesis of 1,2,4-Triazoles and 1,3,5-Triazines from Amidines

A facile and versatile catalytic system involving copper catalyst, K3PO4 as the base, and O2 as the oxidant has been developed to enable efficient synthesis of 2,4,6-trisubstituted and 2,6-disubstituted 1,3,5-triazines and