118967-32-1Relevant articles and documents
SYNTHESIS OF QUINOLINE-4-CARBOXYLIC ACID AND ITS DERIVATIVES
Brasyunas, V.B.,Andreyanova, T.A.,Safonova, T.S.,Solov'eva, N.P.,Turchin, K.F.,Sheinker, Yu.N.
, p. 670 - 673 (1988)
2-Methylquinoline-4-carboxylic acid was obtained by the reaction of isatin with acetone in the presence of alkali.This acid was converted through a step involving (E)-2-styrylquinoline-4-carboxylic acid to quinoline-2,4-dicarboxylic acid, from which quinoline-4-carboxylic acid was obtained by refluxing in nitrobenzene.The structures of the synthesized compounds were confirmed by 1H NMR spectroscopy using two-dimensional (2DJ) spectra.