1189975-18-5

Basic information

• Product Name: [4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide
• Synonyms: [4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide;4-(4-Aminophenoxy)-N-(methyl-d3)-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-(methyl-d3)picolinamide;4-[[2-[N-(Methyl-d3)carbamoyl]-4-pyridyl]oxy]anilin;4-[[2-[N-(Methyl-d3)carbamoyl]-4-pyridyl]oxy]aniline
• CAS NO: 1189975-18-5
• Molecular Formula: C₁₃H₁₃N₃O₂
• Molecular Weight: 246
• Product Categories: Aromatics Compounds;Aromatics;Bases & Related Reagents;Heterocycles;Isotope Labeled Compounds;Nucleotides;Isotope Labelled Compounds
• Mol File: 1189975-18-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: [4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide(1189975-18-5)
• EPA Substance Registry System: [4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide(1189975-18-5)

Safety Data

• Hazardous Substances Data: 1189975-18-5(Hazardous Substances Data)

Usage

General Description

[4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide is a chemical compound with a complex structure, containing a combination of aminophenoxy, pyridyl, and carboxamide groups. The presence of both aminophenoxy and pyridyl moieties suggests potential applications in pharmaceuticals and organic synthesis due to their favorable reactivity and biological activity. The N-(methyl-d3)carboxamide group indicates a presence of deuterium atoms, which may offer unique properties for use in isotopic labeling and studies of metabolic pathways. [4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide may have potential applications in medicinal chemistry, drug discovery, and biochemical research due to its diverse functional groups and potential for isotopic labeling. Its unique structure and properties make it a valuable tool in the field of organic chemistry and chemical synthesis.

Upstream product

• 5470-22-4 4-chloropicolinic acid 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 98-98-6 2-Picolinic acid 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 59-67-6 nicotinic acid 
• 1189858-48-7 4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide) 
• 123-30-8 4-amino-phenol 

Downstream Products

• 1130115-44-4 N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d₃)aminoformyl)-4-pyridyloxy)phenyl)urea 
• 1333386-17-6 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxyl)-2-(N-1’,1’,1’-trideuteromethyl)pyridine amide p-toluenesulfonate 

Relevant articles and documents

Synthesis of deuterium-enriched sorafenib derivatives and evaluation of their biological activities

Deuterium substitution has been widely known that can improve the pharmacokinetic profiles due to isotope effect. Herein, a series of deuterated sorafenib derivatives have been synthesized and characterized by 1H NMR, 13C NMR and MS. Their antitumor activities were evaluated in vitro against human hepatoma cell line HepG2 and human cervical carcinoma cell line HeLa. The LogP values were detected by high-performance liquid chromatography. Subsequently, the metabolic stability and pharmacokinetics study were assessed in vitro and in vivo.

Deuterated bisarylurea compound and preparation method thereof, and application of compound in preparation of antitumor drug

The invention provides a deuterated bisarylurea compound and a preparation method thereof, and application of the compound in preparation of an antitumor drug. The compound has a structure as shown in a general formula (I). The preparation method comprises the following steps: with methyl 4-chloropyridine-2-formate as a raw material, sucjecting methyl 4-chloropyridine-2-formate and methylamine or deuterated methylamine to a substitution reaction; then subjecting a product obtained in the previous step to condensation with p-aminophenol or deuterated p-aminophenol; and reacting a product obtained in the previous step with 4-chloro-3-(trifluoromethyl)phenyl isocyanate or deuterated 4-chloro-3-(trifluoromethyl)phenyl isocyanate so as to prepare the deuterated bisarylurea compound. Experiment results show that the deuterated bisarylurea compound provided by the invention has tumor treatment effect. The invention also provides application of the compound to research and development of the antitumor drug.

PREPARATION METHOD OF FLUORO-SUBSTITUTED DEUTERATED DIPHENYLUREA

A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof.