1190383-75-5

Upstream product

• 141-97-9 ethyl acetoacetate 
• 121641-60-9 ethyl 2-(4-methylphenylimino)acetate 
• 924-44-7 glyoxylic acid ethyl ester 
• 106-49-0 p-toluidine 
• 21911-68-2 ethyl 2-(p-tolylamino)acetate 
• 104-94-9 4-methoxy-aniline 
• 1190383-94-8 diethyl 2-acetyl-3-(p-tolylamino)succinate 

Relevant academic research and scientific papers

Cascade cyclization of glycine derivatives with β-ketoesters for polysubstituted 1,4-dihydropyridines by visible light photoredox catalysis

Visible light photocatalytic cascade cyclization reaction between glycine derivatives and β-ketoesters using Ir (ppy)3 as a catalyst and dicumyl peroxide (DCP) as an oxidant was described. A series of N-aryl glycine esters proceeded the cyclization smoothly with β-ketoesters at room temperature, affording the desired 1,4-dihydropyridines (1,4-DHPs) in satisfactory yields. A possible mechanism for the cascade cyclization reaction by visible light photoredox catalysis was also proposed. This protocol not only provides an efficient and convenient approach to synthetize various 1,4-dihydropyridines, but also has potential utilities for the construction of bioactive molecules.

Copper-Catalyzed Aerobic Cascade Oxidative Coupling/Cyclization for the Construction of 1,4-Dihydropyridine Derivatives

An efficient copper-catalyzed cascade cyclization reaction for the preparation of polysubstituted 1,4-dihydropyridines between N-arylglycine esters and 1,3-dicarbonyl compounds using molecular oxygen as the terminal oxidant has been described. Various N-arylglycine esters 1 and 1,3-dicarbonyl compounds 2 were able to undergo the cascade reaction smoothly to afford the desired products 3 in satisfactory yields. The cascade reaction has the advantages of good functional group tolerance and mild reaction conditions. A possible mechanism has also been proposed on the basis of control experiments.

Catalytic oxidation of C(sp3)-H bonds induced by a radical cation salt: Construction of 1,4-dihydropyridines using a fragment-reassembly strategy

A fragment-reassembly strategy was applied to the construction of 1,4-dihydropyridines and phosphorus-substituted 1,4-dihydropyridines under catalytic radical cation salt-induced C(sp)3-H functionalization of glycine derivatives. Mechanistic studies show that domino C(sp)3-H bond oxidation and C-N bond cleavage reactions are involved.

Multicomponent reactions leading to symmetric and asymmetric multi-substituted 1,4-dihydropyridines on montmorillonite

Highly functionalized multi-substituted symmetric and asymmetric 1,4-dihydropyridines were concisely synthesized in moderate to good yields via one-pot multicomponent reactions (MCRs) of β-dicarbonyl compounds, aldehydes and amines at room temperature on

Synthesis of new 1, 4-Dihydropyridines by addition-rearrangement process with imine derivatives and β-Ketoester as starting materials in solvent-free conditions

N-substituted 1, 4-dihydropyridines bearing a carboxyl group at the 4-position were synthesized in solvent-free conditions with Cu2+ as the catalyst, imine and β-ketoester as starting materials. The possible mechanism which consists of addition