119047-07-3

Upstream product

• 143-33-9 sodium cyanide 
• 108-95-2 phenol 
• 2120-70-9 2-phenoxyethanal 
• 119046-98-9 (S)-2-((1R,3R)-3-Hydroxy-1-methyl-butoxy)-3-phenoxy-propionitrile 
• 32438-31-6 (2,2-diethoxy-ethoxy)-benzene 
• 122-60-1 Phenyl glycidyl ether 
• 538-43-2 3-phenoxy-1,2-propanediol 
• 151-50-8 potassium cyanide 
• 119047-03-9 (S)-2-((R)-1-Methyl-3-oxo-butoxy)-3-phenoxy-propionitrile 
• 119046-95-6 (4R,6R)-4,6-Dimethyl-2-phenoxymethyl-[1,3]dioxane 

Downstream Products

• 112243-65-9 (S)-2-hydroxy-3-phenoxypropylamine 
• 113080-12-9 (S)-phenoxyacetaldehyde cyanohydrin acetate 
• 62372-05-8 1-(N-Propionyl-isopropylamino)-3-phenoxy-2-propionyloxy-propan 
• 62372-02-5 1,1-Dideuterio-1-isopropylamino-3-phenoxy-2-propanol 
• 62372-04-7 1-(N-Methyl-isopropylamino)-3-phenoxy-2-propanol 
• 7695-63-8 (+/-)-1-isopropylamino-3-phenoxypropan-2-ol 
• 250670-80-5 (S)-2-Hydroxy-3-phenoxy-propionitrile 
• 250670-80-5 (R)-2-Hydroxy-3-phenoxy-propionitrile 
• 62372-01-4 1-Amino-1,1-dideuterio-3-phenoxy-2-propanol 
• 4287-19-8 1-amino-3-phenoxy-isopropanol 
• 106985-59-5 phenoxyacetaldehyde cyanohydrin acetate 

Relevant academic research and scientific papers

Formation of Optically Active Aryloxyacetaldehyde Cyanohydrin Acetates with the Aid of a Microorganism

Microorganisms that hydrolyze the one enantiomer of dl-phenoxyacetaldehyde cyanohydrin acetate were screened, and Bacillus coagulans isolated from soil was found to be the best.This bacterium was applied to the asymmetric hydrolysis of other aryloxyacetaldehyde derivatives to give satisfactory results.The effect of adding dimethyl sulfoxide to the medium is also described.

TiCl4 Induced Opening of Chiral Acetals: a route to β-adrenergic blocking agents

Aryloxy and alkyloxypropanolamines 7a-c are obtained in 45 to 70 percent yields and with asymmetric induction, using TiCl4 induced nucleophilic addition of cyanotrimethylsilane onto chiral acetals derived from racemic 2,4-pentanediol.Therefore, optically pure 2,4-pentanediol will provide, after a purification, optically pure 7a-c.

Process for manufacturing phenoxylactic acids, their derivatives and products obtained thereby

The process is for the manufacture of phenoxylactic acids and their derivatives of the general formula: STR1 (in which R1 and R2, identical or different, can represent hydrogen atoms, methyl residues, methoxy groups or halogens; Y re