119216-06-7

Upstream product

• 141-30-0 3,6-dichlorpyridazine 
• 611-74-5 N,N-dimethylbenzamide 
• 6531-08-4 3,6-dichloropyridazine-5-carboxylic acid chloride 
• 71-43-2 benzene 
• 98-88-4 benzoyl chloride 
• 98-87-3 benzylidene dichloride 
• 611-73-4 Benzoylformic acid 
• 1104202-03-0 C₈H₂Cl₄N₄Zn 
• 100-52-7 benzaldehyde 
• 130825-19-3 3,6-dichloro-4-(1-hydroxyphenylmethyl)pyridazine 

Downstream Products

• 145355-23-3 (3-amino-6-chloro-4-pyridazinyl) phenyl ketone 
• 145355-24-4 (6-amino-3-chloro-4-pyridazinyl) phenyl ketone 
• 145355-22-2 (3-benzylamino-6-chloro-4-pyridazinyl) phenyl ketone 
• 1104202-11-0 (5-benzoyl-3,6-dichloro-pyridazin-4-yl)-phenyl-methanone 
• 145355-26-6 (3-amino-4-pyridazinyl)phenylmethanol 
• 145355-25-5 (3-amino-4-pyridazinyl) phenyl ketone 
• 145355-34-6 3-Chloro-7-(4-ethyl-piperazin-1-yl)-5-phenyl-pyrido[2,3-c]pyridazine 
• 145355-33-5 3-chloro-7-(4-methylpiperazinyl)-5-phenylpyrido<2,3-c>pyridazine 
• 145355-36-8 7-(4-ethylpiperazinyl)-5-phenylpyrido<2,3-c>pyridazine 
• 145355-28-8 3-chloro-7-ethoxy-5-phenylpyrido<2,3-c>pyridazine 
• 145355-31-3 3-chloro-7-dimethylamino-5-phenylpyrido<2,3-c>pyridazine 
• 145355-29-9 N-(4-benzoyl-6-chloro-3-pyridazinyl)acetamide 
• 145355-30-2 3-chloro-7,8-dihydro-7-oxo-5-phenylpyrido<2,3-c>pyridazine 
• 145355-35-7 7-dimethylamino-5-phenylpyrido<2,3-c>pyridazine 

Relevant academic research and scientific papers

Ag-catalyzed decarboxylative acylation of pyridazines using α-keto acids in aqueous media

An efficient and general protocol for Ag-Catalyzed decarboxylative acylation of pyridazines using α-keto acids as acylation reagent in aqueous media has been described. This method provides a new avenue for the synthesis of diverse array of acylated pyridazines with different substitution patterns. The reaction proceeds smoothly in water under mild conditions and exhibits a good functional group tolerance.

Benzoyl pyridazine derivative and preparation method thereof

The invention relates to a benzoyl pyridazine derivative and a preparation method thereof, and belongs to the technical field of pyridazine compound synthesis. The benzoyl pyridazine derivative disclosed by the invention has a structure as shown in a form

α-Chlorobenzylation of Nitroarenes via Vicarious Nucleophilic Substitution with Benzylidene Dichloride: Umpolung of the Friedel-Crafts Reaction

Readily available α,α-dichlorotoluenes enter a vicarious nucleophilic substitution (VNS) reaction with electron-deficient arenes to give α-chlorobenzylated nitrobenzenes, as well as six- and five-membered heterocycles. Oxidation of the initially formed α-chlorobenzylic carbanions instead of protonation results in formation of diaryl ketones, providing a means for overall nucleophilic C-H benzoylation of electron-deficient aromatic rings. Alternatively, benzoylated nitroarenes can be obtained via the reaction of isolated α-chlorodiarylmethanes with sodium azide.

Air-stable solid aryl and heteroaryl organozinc pivalates: Syntheses and applications in organic synthesis

A wide range of air-stable, solid, polyfunctional aryl and heteroarylzinc pivalates were efficiently prepared by either magnesium insertion or Hal/Mg exchange followed by transmetalation with Zn(OPiv)2 (OPiv=pivalate). By reducing the amount of

Novel access to 1,4-benzodiazepin-2-ones via the Buchwald reaction and application to the synthesis of novel heterocyclics

A new two step strategy for the preparation of 1,4-benzodiazepin-2-ones has been developed starting from the 2-halogenobenzophenone under Buchwald conditions (Pd(OAc)2, XantPhos, Cs2CO3, dioxane 100 °C). This strategy has

Efficient mono- and bis-functionalization of 3,6-dichloropyridazine using (tmp)2Zn·2MgCl2·2LiCl

3,6-Dichloropyridazine undergoes a smooth metallation using (tmp) 2Zn·2MgCl2·2LiCl. The resulting bis-organozinc species react with various electrophiles; subsequent functionalization via a second metallation proceeds readily; further reactions with hydrazine lead to highly substituted pyrazolo[3,4-c]pyridazines derivatives. The Royal Society of Chemistry 2008.

Metallation of Diazines II. First Metallation of Pyridazine, Metallation of 2,4-Dichloropyrimidine

3,6-Dichloropyridazine was ortho-lithiated by lithium 2,2,6,6-tetramethylpiperidide.The resulting lithio compound was reacted with carbonyl derivatives iodine, iodine and trimethylchlorosilane.An azaxanthone was synthesized.An unusual regioselectivity for the lithiation of 2,4-dichloropyrimidine was studied.

Synthesis of New Aryl (3,6-Dichloro-4-pyridazinyl) Ketones and their Reaction with N,N-Dinucleophiles

The synthesis of new aryl (3,6-dichloro-4-pyridazinyl)ketones 3a-e via Friedel-Crafts acylation of the aromatic compounds 2a-e with 3,6-dichloro-4-pyridazinecarbonyl chloride (1) is described.The ketones 3a-e are cyclized with N,N-dinucleophilic reagents to the 3-aryl-5-chloro-1H-pyrazolopyridazines 4a-d, and 3a-c are converted into the 3-aryl-5-chloro-1H-pyrazolopyridazin-1-ethanols 5a-c and to the hitherto unknown ring system of the 5-aryl-3-chloro-7,8-dihydro-9H-pyridazinodiazepines (6a-c).