1193-10-8Relevant articles and documents
Hetero-Diels-Alder Addition of Sulfur Dioxide to 1,3-Dienes. Suprafaciality, Regioselectivity, and Stereoselectivity
Deguin, Brigitte,Vogel, Pierre
, p. 9210 - 9211 (1992)
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Diversity oriented approach to phenylalanine derivatives via the dielsalder reaction involving sulfolene intermediates
Kotha, Sambasivarao,Bandi, Vijayalakshmi
, p. 226 - 237 (2015)
We report a new synthetic approach to highly functionalized phenylalanine derivatives via sulfolenes as latent diene equivalents. Here, the DielsAlder reaction has been used as a key step to assemble diverse unusual amino acid derivatives.
Revisiting the Male-Produced Aggregation Pheromone of the Lesser Mealworm, Alphitobius diaperinus (Coleoptera, Tenebrionidae): Identification of a Six-Component Pheromone from a Brazilian Population
Hassemer, Marla J.,Sant'Ana, Josué,Borges, Miguel,Withall, David,Pickett, John A.,De Oliveira, Márcio W.M.,Laumann, Raul A.,Birkett, Michael A.,Blassioli-Moraes, Maria C.
, p. 6809 - 6818 (2016)
The lesser mealworm, Alphitobius diaperinus Panzer 1797 (Coleoptera: Tenebrionidae), is a cosmopolitan insect pest affecting poultry production. Due to its cryptic behavior, insecticide control is usually not efficient. Thus, sustainable and effective methods would have an enormous and positive impact in poultry production. The aim of this study was to confirm the identity of the male-produced aggregation pheromone for a Brazilian population of A. diaperinus and to evaluate its biological activity in behavioral assays. Six male-specific compounds were identified: (R)-limonene (1), (E)-ocimene (2), 2-nonanone (3), (S)-linalool (4), (R)-daucene (5), all described before in an American population, and a sixth component, (E,E)-α-farnesene (6), which is apparently exclusive to a Brazilian population. Y-Tube bioassays confirmed the presence of a male-produced aggregation pheromone and showed that all components need to be present in a similar ratio and concentration as emitted by male A. diaperinus to produce a positive chemotactic response.
Design, synthesis and biological evaluation of novel riccardiphenol analogs
Kumar, Srinivas K.,Amador, Maria,Hidalgo, Manuel,Bhat, Sujata V.,Khan, Saeed R.
, p. 2873 - 2880 (2007/10/03)
A novel, facile, high yield, and less cumbersome synthesis of riccardiphenol analogs is described. The synthesized compounds were characterized and assessed for its in vitro activity in a panel of human cancer cell lines of differing origin: HuCCT-1, BxPC3, Panc-1, Mia-Paca, A431, Hep2, and HN006. HuCCT-1 was derived from an intrahepatic cholangiocarcinoma; BxPC3, Mia-Paca, and Panc-1 were derived from pancreatic cancers; A431 was derived from a vulvar epithelial carcinoma; and Hep2 and HN006 were derived from squamous cell carcinomas of the head and neck. The cytotoxicity of a newly developed riccardiphenol analog against human cancer cell lines was assessed. The cancer cells exhibited varying sensitivities to the compound, with IC50 values from 30 to 50 μM. This susceptibility was particularly interesting in the case of lines such as Hep2 and BxPC3 that are resistant to classic cytotoxic drugs as well as some targeted agents. These results demonstrate that the novel riccardiphenol analog has effective action against human-derived cancer cell in vitro.
