1193-70-0Relevant articles and documents
Regioselective ketone α-alkylation with simple olefins via dual activation
Mo, Fanyang,Dong, Guangbin
, p. 68 - 72 (2014/07/21)
Alkylation of carbonyl compounds is a commonly used carbon-carbon bond-forming reaction. However, the conventional enolate alkylation approach remains problematic due to lack of regioselectivity, risk of overalkylation, and the need for strongly basic conditions and expensive alkyl halide reagents. Here, we describe development of a ketone-alkylation strategy using simple olefins as the alkylating agents. This strategy employs a bifunctional catalyst comprising a secondary amine and a low-valent rhodium complex capable of activating ketones and olefins simultaneously. Both cyclic and acyclic ketones can be mono-a-alkylated with simple terminal olefins, such as ethylene, propylene, 1-hexene, and styrene, selectively at the less hindered site; a large number of functional groups are tolerated.The pH/redox neutral and byproduct-free nature of this dual-activation approach shows promise for large-scale syntheses.
Intramolecular schmidt reaction involving primary azidoalcohols under nonacidic conditions: Synthesis of indolizidine (-)-167B
Kapat, Ajoy,Nyfeler, Erich,Giuffredi, Guy T.,Renaud, Philippe
supporting information; experimental part, p. 17746 - 17747 (2010/04/01)
(Chemical Equation Presented) A powerful intramolecular Schmidt reaction starting from primary azidoalcohols is reported. This approach involves a nonacidic activation of the alcohol via triflation. The synthetic potential offered by the mild reaction con
Amidino dervatives useful as nitric oxide synthase inhibitors
-
, (2008/06/13)
The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
