1193-74-4

Basic information

• Product Name: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)
• Synonyms: 2-Pyrimidinamine, 4,5-dimethyl- (9CI);4,5-Dimethylpyrimidin-2-amine;(4,5-dimethylpyrimidin-2-yl)amine;4,5-dimethyl-2-pyrimidinamine
• CAS NO: 1193-74-4
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.15576
• Product Categories: PYRIMIDINE
• Mol File: 1193-74-4.mol

Chemical Properties

• Melting Point: 215.8°C
• Boiling Point: 219.27°C (rough estimate)
• Flash Point: 161.7°C
• Appearance: /
• Density: 1.1097 (rough estimate)
• Vapor Pressure: 0.00102mmHg at 25°C
• Refractive Index: 1.5589 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)(1193-74-4)
• EPA Substance Registry System: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)(1193-74-4)

Safety Data

• Hazardous Substances Data: 1193-74-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrimidinamine, 4,5-dimethyl(9CI) is used as an intermediate in the synthesis of various pharmaceutical compounds. Its reactivity and properties make it a valuable component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Pyrimidinamine, 4,5-dimethyl(9CI) is utilized as an intermediate for the production of various agrochemicals. Its unique properties contribute to the development of effective and efficient products for agricultural applications.
Used in Organic Compounds Synthesis:
2-Pyrimidinamine, 4,5-dimethyl(9CI) is also used as an intermediate in the synthesis of other organic compounds. Its versatility and reactivity make it a valuable component in the creation of a wide range of organic substances.
Proper handling and storage of 2-Pyrimidinamine, 4,5-dimethyl(9CI) are essential to ensure safety and prevent any potential hazards. As with all chemicals, it is crucial to follow appropriate safety guidelines and protocols when working with 2-Pyrimidinamine, 4,5-dimethyl- (9CI).

InChI:InChI=1/C6H9N3/c1-4-3-8-6(7)9-5(4)2/h3H,1-2H3,(H2,7,8,9)

Upstream product

• 14394-61-7 2-amino-4-chloro-5,6-dimethyl-pyrimidine 
• 41850-84-4 1-methoxy-2-methyl-1-buten-3-one 
• 506-93-4 guanidine nitrate 
• 593-85-1 diguanidine carbonate 
• 64-17-5 ethanol 
• 50421-80-2 4-hydroxy-3-methyl-but-3-en-2-one 
• 22428-91-7 2-methyl-3-oxobutanal 
• 7732-18-5 water 
• 1780-32-1 2,4-dichloro-5,6-dimethylpyrimidine 
• 50-01-1 guanidine hydrochloride 
• 1679-40-9 3-chloro-2-methyl-2-butenal 

Downstream Products

• 4462-43-5 2-sulfanilamido-4,5-dimethylpyrimidine 
• 857950-59-5 N-acetyl-sulfanilic acid-(4,5-dimethyl-pyrimidin-2-ylamide) 

Relevant articles and documents

Efficient synthesis of 4- And 5-substituted 2-aminopyrimidines by coupling of β-Chlorovinyl Aldehydes and Guanidines

A general, practical, and simple synthesis of functionalized 2-aminopyrimidines starting from β-chlorovinyl aldehydes and amidines is reported. In the presence of potassium carbonate, various ketones have been efficiently transformed into the pyrimidine derivatives by a two-step sequence involving the Vilsmeier-Haack reaction followed by a condensation reaction with guanidines. The protocol is distinguished by operational simplicity, inexpensive reagents, and functional-group tolerance. In many cases, pure solid products can be obtained in high to excellent yields without using column chromatography. The synthetic value of the method was demonstrated by the efficient synthesis of steroidal pyrimidines and a precursor of the antitumor agents Imatinib and Mocetinostat.

Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.