1193-74-4

Basic information

• Product Name: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)
• Synonyms: 2-Pyrimidinamine, 4,5-dimethyl- (9CI);4,5-Dimethylpyrimidin-2-amine;(4,5-dimethylpyrimidin-2-yl)amine;4,5-dimethyl-2-pyrimidinamine
• CAS NO: 1193-74-4
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.15576
• Product Categories: PYRIMIDINE
• Mol File: 1193-74-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 215.8°C
• Boiling Point: 219.27°C (rough estimate)
• Flash Point: 161.7°C
• Appearance: /
• Density: 1.1097 (rough estimate)
• Vapor Pressure: 0.00102mmHg at 25°C
• Refractive Index: 1.5589 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)(1193-74-4)
• EPA Substance Registry System: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)(1193-74-4)

Safety Data

• Hazardous Substances Data: 1193-74-4(Hazardous Substances Data)

Usage

General Description

2-Pyrimidinamine, 4,5-dimethyl- (9CI) is a chemical compound with the molecular formula C7H9N3. It is also known by the name 4,5-dimethylpyrimidin-2-amine. This chemical is a crystalline solid with a faint odor and is soluble in water. It is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. Its precise uses and applications in various industries depend on its specific properties and reactivity. As with all chemicals, proper handling and storage of 2-Pyrimidinamine, 4,5-dimethyl- (9CI) are important to ensure safety and prevent any potential hazards.

InChI:InChI=1/C6H9N3/c1-4-3-8-6(7)9-5(4)2/h3H,1-2H3,(H2,7,8,9)

Upstream product

• 14394-61-7 2-amino-4-chloro-5,6-dimethyl-pyrimidine 
• 22428-91-7 2-methyl-3-oxobutanal 
• 506-93-4 guanidine nitrate 
• 593-85-1 diguanidine carbonate 
• 7732-18-5 water 
• 50-01-1 guanidine hydrochloride 
• 1679-40-9 3-chloro-2-methyl-2-butenal 
• 1780-32-1 2,4-dichloro-5,6-dimethylpyrimidine 
• 64-17-5 ethanol 
• 50421-80-2 4-hydroxy-3-methyl-but-3-en-2-one 
• 41850-84-4 1-methoxy-2-methyl-1-buten-3-one 

Downstream Products

• 857950-59-5 N-acetyl-sulfanilic acid-(4,5-dimethyl-pyrimidin-2-ylamide) 
• 4462-43-5 2-sulfanilamido-4,5-dimethylpyrimidine 

Relevant articles and documents

Efficient synthesis of 4- And 5-substituted 2-aminopyrimidines by coupling of β-Chlorovinyl Aldehydes and Guanidines

A general, practical, and simple synthesis of functionalized 2-aminopyrimidines starting from β-chlorovinyl aldehydes and amidines is reported. In the presence of potassium carbonate, various ketones have been efficiently transformed into the pyrimidine derivatives by a two-step sequence involving the Vilsmeier-Haack reaction followed by a condensation reaction with guanidines. The protocol is distinguished by operational simplicity, inexpensive reagents, and functional-group tolerance. In many cases, pure solid products can be obtained in high to excellent yields without using column chromatography. The synthetic value of the method was demonstrated by the efficient synthesis of steroidal pyrimidines and a precursor of the antitumor agents Imatinib and Mocetinostat.

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.