119340-78-2

Upstream product

• 505-23-7 1,3 dithiane 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 31593-52-9 2-benzyl-1,3-dithiane 
• 122-78-1 phenylacetaldehyde 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 1372129-45-7 C₁₇H₁₅NO₄ 
• 1372129-57-1 C₁₇H₁₅NO₄ 
• 1372129-60-6 (Z)-methyl 3-(4-methoxyphenyl)-2-methyl-4-phenyl-2-butenoate 
• 665004-92-2 (Z)-2-methyl-3-trimethylsilyl-4-phenyl-2-butenoic acid 
• 1416889-51-4 (2S,3R)-4-nitro-2,3-diphenyl-1-(trimethylsilyl)butan-1-one 
• 5460-60-6 N-phenethyl-2-phenylacetamide 
• 7500-45-0 N-benzylphenylacetamide 
• 56583-94-9 (phenylacetyl)trimethylsilane 

Relevant academic research and scientific papers

Intermolecular Schmidt reaction of alkyl azides with acyl silanes

The first intermolecular Schmidt reaction of alkyl azides with acyl silanes has been designed and realized, producing a range of amides with absolute site selectivity in good to excellent yields. The mechanism of the conversion has been proposed, and the reaction exhibits scope of substrates.

Organocatalytic asymmetric Michael reaction with acylsilane donors

We have developed an organocatalytic asymmetric Michael reaction of acylsilane through the selection of acylsilane substrates and organocatalysts, thus creating a rare example of acylsilane α-alkylation with a chiral guanidine catalyst, which afforded pro

Palladium-catalyzed fluoride-free cross-coupling of intramolecularly activated alkenylsilanes and alkenylgermanes: Synthesis of tamoxifen as a synthetic application

We have demonstrated that intramolecular hypercoordination of a carboxylic acid is a powerful activation strategy for the palladium-catalyzed cross-coupling reaction of trialkyl(vinyl)silanes and trialkyl(vinyl)germanes under fluoride-free conditions. Z-β-Trialkylsilyl- and Z-β- trialkylgermylacrylic acids, synthesized stereoselectively by olefination with ynolates, are highly stable and useful reagents for cross-coupling with a variety of aryl iodides to provide tetrasubstituted olefins possessing different carbon substituents in a stereocontrolled and diversity-oriented manner. An application to a stereoselective synthesis of (Z)-tamoxifen is also reported. Copyright

Synthesis of acylsilanes via oxidative hydrolysis of 2-silyl-1,3-dithianes mediated by N-bromosuccinimide

The oxidative method for the hydrolysis of 1,3-dithianes was applied to 2-silyl-1,3-dithianes using N-bromosuccinimide providing acylsilanes with good yields under a short reaction period. The oxidation of aroylsilanes to carboxylic acid was prevented by

Substituted silyl alkylene amines

This invention relates to substituted silyl alkylene amines, to the intermediates and processes useful for their preparation, to their pharmacological use as MAO-B inhibitors and to their end-use application in the treatment of Parkinson's Disease and senile dementia of Alzheimer's type.

Counterattack Reagent: Hexamethyldisilane in a Direct Synthesis of Ketene Dithioacetals and 2-Trimethylsilyl-1,3-dithiane Derivatives from 1,3-Dithiane

A novel method has been developed for the direct synthesis of ketene dithioacetals and 2-trimethylsilyl-1,3-dithiane derivatives from 1,3-dithiane.Treatment of 1,3-dithiane (1.0 mol equiv.) with BuLi (1.1 mol equiv.), HMPA (4.0 mol equiv.), and Me3SiSiMe3