119540-36-2

Upstream product

• 3471-32-7 4-Methoxyphenylhydrazine 
• 119540-32-8 ethyl 1-(4-methoxyphenyl)-5-(4-methylphenyl)pyrazole-3-carboxylate 
• 119540-34-0 3-Hydroxymethyl-1-(4-methoxyphenyl)-5-(4-methylphenyl)pyrazole 

Downstream Products

• 119577-24-1 3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-2-naphthalen-1-yl-propionic acid ethyl ester 
• 119540-43-1 3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-2-pyridin-2-yl-propionic acid ethyl ester 
• 119540-44-2 2-Biphenyl-4-yl-3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-propionic acid ethyl ester 
• 119540-42-0 2-(2-Methoxy-phenyl)-3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-propionic acid ethyl ester 
• 1000805-24-2 3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid ethyl ester 
• 648863-04-1 3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-2-m-tolyl-propionitrile 
• 648864-52-2 3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid 
• 648861-60-3 3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid 

Relevant academic research and scientific papers

SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists

A high throughput screening campaign revealed compound 1 as a potent antagonist of the human CCK1 receptor. Here, we report the syntheses and SAR studies of 1,5-diarylpyrazole analogs with various structural modifications of the alkane side cha

Alpha,beta-unsaturated esters and acids by stereoselective dehydration

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, methods for making the same, and stereoselective dehydration methods for generally making α,β-unsaturated esters, acids and their derivatives.

Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity

High throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Evaluation of the CCK1 SAR in a series of these diarylpyrazole antagonists was conducted in a matrix synthesis format revealing additive (Free

CCK-1 RECEPTOR MODULATORS

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: (I) wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, and methods of making the same.

CCK-1 RECEPTOR MODULATORS

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.

Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides

2- and 3-substituted (1',5'-diaryl-3'-pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.