648864-52-2

Upstream product

• 3471-32-7 4-Methoxyphenylhydrazine 
• 119540-32-8 ethyl 1-(4-methoxyphenyl)-5-(4-methylphenyl)pyrazole-3-carboxylate 
• 119540-34-0 3-Hydroxymethyl-1-(4-methoxyphenyl)-5-(4-methylphenyl)pyrazole 
• 119540-36-2 3-Bromomethyl-1-(4-methoxyphenyl)-5-(4-methylphenyl)pyrazole 
• 1000805-24-2 3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid ethyl ester 

Downstream Products

• 648862-87-7 3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-2-m-tolyl-propionamide 

Relevant academic research and scientific papers

SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists

A high throughput screening campaign revealed compound 1 as a potent antagonist of the human CCK1 receptor. Here, we report the syntheses and SAR studies of 1,5-diarylpyrazole analogs with various structural modifications of the alkane side cha

Alpha,beta-unsaturated esters and acids by stereoselective dehydration

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, methods for making the same, and stereoselective dehydration methods for generally making α,β-unsaturated esters, acids and their derivatives.

Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity

High throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Evaluation of the CCK1 SAR in a series of these diarylpyrazole antagonists was conducted in a matrix synthesis format revealing additive (Free

CCK-1 RECEPTOR MODULATORS

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.