120106-67-4

Upstream product

• 591-50-4 iodobenzene 
• 1009089-47-7 1‐benzyl‐4‐(4‐chlorophenyl)‐1H‐1,2,3‐triazole 
• 5172-02-1 1-chloro-4-(2-phenylethynyl)benzene 
• 100-52-7 benzaldehyde 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 
• 100-47-0 benzonitrile 
• 623-03-0 4-Cyanochlorobenzene 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 908094-04-2 phenyldiazomethane 

Downstream Products

• 1025357-96-3 1-[4-(p-chlorophenyl)-5-phenyl-[1,2,3]triazol-2-yl]-3-bromopropane 
• 1024655-85-3 2-(4-bromobenzyl)-4-(p-chlorophenyl)-5-phenyl-2H-[1,2,3]triazole 
• 1024655-90-0 1-(4-bromobenzyl)-4-(p-chlorophenyl)-5-phenyl-1H-[1,2,3]triazole 
• 1024655-95-5 1-(4-bromobenzyl)-5-(p-chlorophenyl)-4-phenyl-1H-[1,2,3]triazole 
• 1024656-40-3 4-(4-chlorophenyl)-2-(ethoxycarbonyl)methyl-5-phenyl-2H-[1,2,3]triazole 
• 1248827-40-8 C₁₈H₁₆ClN₃O₂ 
• 1248827-38-4 C₁₈H₁₆ClN₃O₂ 
• 1024656-05-0 1-benzyl-4-(4-chlorophenyl)-5-phenyl-1H-[1,2,3]triazole 
• 1024656-00-5 2-benzyl-4-(4-chlorophenyl)-5-phenyl-2H-[1,2,3]triazole 
• 1024655-59-1 5-(4-chlorophenyl)-1-pentyl-4-phenyl-1H-[1,2,3]triazole 
• 1024655-54-6 4-(4-chlorophenyl)-1-pentyl-5-phenyl-1H-[1,2,3]triazole 
• 1024655-49-9 4-(4-chlorophenyl)-2-pentyl-5-phenyl-2H-[1,2,3]triazole 
• 1024655-75-1 4-(4-chlorophenyl)-1-heptyl-5-phenyl-1H-[1,2,3]triazole 
• 1024655-80-8 5-(4-chlorophenyl)-1-heptyl-4-phenyl-1H-[1,2,3]triazole 

Relevant academic research and scientific papers

Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles

Intermolecular cycloaddition of tosylhydrazones with nitriles was investigated. t -BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol, and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H -1,2,3-triazoles were prepared in good to excellent yields and with high purities. The process is azide-free and transition-metal-free.

Pd-catalyzed ligand-free C(5)–H arylation of 1,4-disubstituted 1,2,3-triazoles promoted by microwaves

Pd(OAc)2-catalyzed regioselective C(5)–H arylation of 1,4-disubstituted 1,2,3-triazoles was achieved without ligand under microwave conditions in 1 h, generating 1,4,5-trisubstituted 1,2,3-triazoles with good to excellent yields. The obtained molecules can be easily converted into 4,5-disubstituted 1,2,3-triazoles through the debenzylation process with one-pot manipulation.

N-substituted-1,2,3-triazoles: Synthesis, characterization and evaluation as cannabinoid ligands

A series of new N1-, N2-and N3-substituted 1,2,3-triazole derivatives has been synthesized by cycloaddition of butyltin azide with substituted alkynes followed by a N-alkylation reaction. The regioisomers have been isolated and characterized using NMR tec

1,2,3- triazole derivatives as sigma receptor inhibitors

The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to 1,2,3-triazole derivatives of formula I and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and prophylaxis, in particular for the treatment of psychosis or pain.

PHOTOCHEMICAL AZIDO LIGAND TRANSFER REACTION OF A TRIARYLBISMUTH DIAZIDE WITH ALKYNES

Irradiation of a triarylbismuth diazide in benzene in the presence of alkynes results in the transfer of one of the azido ligands to the triple bond, leading to N-unsubstituted 1,2,3-triazoles in fair to moderate yields.

THE REACTIONS OF HYDRAZONES AND RELATED COMPOUNDS WITH STRONG BASES. PART 4. 4,5-DIARYL-1,2,3-TRIAZOLES FROM AROMATIC ALDEHYDE AZINES AND FROM THE REACTION OF ARENECARBONITRILES WITH ARYLDIAZOMETHANES

Reaction of aromatic aldehyde azines in dimethyl sulphoxide at 20 deg C with potassium t-butoxide gave 4,5-diaryl-1,2,3-triazoles (4) and stilbenes.Mechanisms were studied by addition of possible intermediates and by (14)C tracer methods.The synthesis of 4,5-diaryl-1,2,3-triazoles from arenecarbonitriles, aryldiazomethanes, and potassium t-butoxide in toluene is described and the mechanism is discussed.