120158-03-4

Basic information

• Product Name: Carbamic acid, (chloroacetyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (chloroacetyl)-, 1,1-dimethylethyl ester (9CI);tert-butyl 2-chloroacetylcarbaMate
• CAS NO: 120158-03-4
• Molecular Formula: C₇H₁₂ClNO₃
• Molecular Weight: 193.62808
• Product Categories: N-BOC
• Mol File: 120158-03-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (chloroacetyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (chloroacetyl)-, 1,1-dimethylethyl ester (9CI)(120158-03-4)
• EPA Substance Registry System: Carbamic acid, (chloroacetyl)-, 1,1-dimethylethyl ester (9CI)(120158-03-4)

Safety Data

• Hazardous Substances Data: 120158-03-4(Hazardous Substances Data)

Upstream product

• 75-65-0 tert-butyl alcohol 
• 79-37-8 oxalyl dichloride 
• 79-07-2 Chloroacetamide 
• 144-55-8 sodium hydrogencarbonate 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 71999-74-1 tert-butyl N-(2-chloroethyl)carbamate 

Downstream Products

• 1005787-84-7 tert-butyl N-[6-iodoimidazo[1,2-b]pyridazin-2-yl]carbamate 
• 79-07-2 Chloroacetamide 

Relevant articles and documents

Rational Design, Synthesis and Evaluation of Novel C6-Bicycloalkaneimidazole Containing Imidazo[1,2-b]pyridazines for ASK1 Inhibition

Apoptosis signal-regulating kinase 1 (ASK1) is a member of mitogen-activated protein kinase kinase kinase (MAP3K) family that involves downstream phosphorylation of MAP kinases, c-Jun N-terminal kinases, and p38 MAP kinases. ASK1 inhibitors could possibly be beneficial for ameliorating the development and progression of diseases. Especially, ASK1 has been of interest as one of therapeutic targets for nonalcoholic fatty liver disease as the most common chronic liver diseases including simple steatosis and nonalcoholic steatohepatitis. In this manuscript, novel ASK1 inhibitor lead KTA-29 which has an imidazo[1,2-b]pyridazine core with novel C6-bicycloheptaneimidazole is disclosed. With the novel imidazo[1,2-b]pyridazine core, structure-activity-relationship study for ASK1 potency is described and KTA-29 affinity toward ASK1 with molecular modeling study is explained.

FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF

The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.