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1203-41-4 Usage

General Description

2'-Methyl-biphenyl-2-ylamine, also known as o-toluidine, is a chemical compound with the molecular formula C13H13N. It is an aromatic amine commonly used in the production of dyes, synthetic resins, and rubber additives. O-toluidine is also used as an intermediate in the manufacturing of pharmaceuticals and agricultural chemicals. Additionally, it is often employed as a chemical intermediate for the synthesis of various substances, including antioxidants, lubricant additives, and corrosion inhibitors. However, o-toluidine is considered to be a hazardous substance and is known to be toxic, as exposure to high levels of this chemical has been associated with adverse health effects, including potential carcinogenicity. Therefore, caution should be exercised when handling and using 2'-methyl-biphenyl-2-ylamine.

Check Digit Verification of cas no

The CAS Registry Mumber 1203-41-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,0 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1203-41:
34 % 10 = 4
So 1203-41-4 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier


1.2 Other means of identification

Product number -
Other names 2'-Methylbiphenyl-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1203-41-4 SDS

1203-41-4Relevant articles and documents

[Ru(TPP)CO]-catalysed intramolecular benzylic C-H bond amination, affording phenanthridine and dihydrophenanthridine derivatives

Intrieri, Daniela,Mariani, Matteo,Caselli, Alessandro,Ragaini, Fabio,Gallo, Emma

, p. 10487 - 10490,4 (2012)

Shedding light on azides: [Ru(TPP)CO] (TPP=tetraphenyl porphyrin dianion), white light and O2 were found to be a suitable catalyst combination to perform the annulation of several biaryl azides (see scheme). The high chemoselectivity of the process allows the synthesis of phenanthridines and dihydrophenanthridines in good yield and purity. Copyright

Synthesis of Triphenylenes Starting from 2-Iodobiphenyls and Iodobenzenes via Palladium-Catalyzed Dual C-H Activation and Double C-C Bond Formation

Zhang, Yanghui,Pan, Shulei,Jiang, Hang,Zhang, Yu,Chen, Dushen

, p. 5192 - 5195 (2016)

A novel and facile approach for the synthesis of triphenylenes has been developed via palladium-catalyzed coupling of 2-iodobiphenyls and iodobenzenes. The reaction involves dual palladium-catalyzed C-H activations and double palladium-catalyzed C-C bond formations. A range of unsymmetrically functionalized triphenylenes can be synthesized with the reaction. The approach features readily available starting materials, high atom- and step-economy, and access to various unsymmetrically functionalized triphenylenes.



, p. 71 (1944)


Visible Light-Induced Radical Cyclization of Tertiary Bromides with Isonitriles to Construct Trifluoromethylated Quaternary Carbon Center

Wang, Wengui,Guo, Yong,Sun, Ke,Wang, Shoufeng,Zhang, Shuxiang,Liu, Chao,Chen, Qing-Yun

, p. 14588 - 14599 (2018)

The reaction of trifluoromethylated tertiary bromides with isonitriles induced by visible light is reported. Defluorination was avoided in a radical process. This method provides an efficient approach to compounds containing a trifluoromethylated quaternary carbon center, most of which show excellent potential to be agrochemicals. In addition, the bromides were prepared from perfluoroisobutylene, which is a waste from industry, after several steps. This reaction shows a feasible transfer of harmful waste into useful compounds.

Scalable electrochemical synthesis of diaryliodonium salts

Elsherbini, Mohamed,Moran, Wesley J.

supporting information, p. 4706 - 4711 (2021/06/11)

Cyclic and acyclic diaryliodonium are synthesised by anodic oxidation of iodobiaryls and iodoarene/arene mixtures, respectively, in a simple undivided electrolysis cell in MeCN-HFIP-TfOH without any added electrolyte salts. This atom efficient process does not require chemical oxidants and generates no chemical waste. More than 30 cyclic and acyclic diaryliodonium salts with different substitution patterns were prepared in very good to excellent yields. The reaction was scaled-up to 10 mmol scale giving more than four grams of dibenzo[b,d]iodol-5-ium trifluoromethanesulfonate (>95%) in less than three hours. The solvent mixture of the large-scale experiment was recovered (>97%) and recycled several times without significant reduction in yield.

Cobalt(II)-Catalyzed [5+2] C?H Annulation of o-Arylanilines with Alkynes: An Expedient Route to Dibenzo-[b,d]azepines

Ling, Fei,Xie, Zhen,Chen, Jiachen,Ai, Chongren,Shen, Haiwei,Wang, Ze,Yi, Xiao,Zhong, Weihui

supporting information, p. 3094 - 3101 (2019/05/21)

The first example of CoCl2-catalyzed formal [5+2] oxidative annulation of o-arylanilines with alkynes was developed, giving access to various important imine-containing dibenzo-[b,d]azepine scaffolds through sequential C?C/C?N bond formation. The reaction employs catalytic amount of manganese and oxygen as cooxidants, and features a broad substrate scope. Preliminary mechanistic studies suggested that C?H activation is involved in the rate-determining step. Moreover, both internal and terminal alkynes are well tolerated in this transformation. Besides, a regioselective migratory insertion was observed when using terminal alkynes as substrates. (Figure presented.).

Palladium-Catalyzed Benzofulvenation of o-Arylanilines through C?H Bond Activation by Using Two Diarylacetylenes as an Implicit Benzofulvene

Raju, Selvam,Hsiao, Huan-Chang,Thirupathi, Selvakumar,Chen, Pei-Ling,Chuang, Shih-Ching

supporting information, p. 683 - 689 (2019/01/04)

We report the first example of Pd(II)-catalyzed highly step- and atom-economical benzofulvenation through free amine-directed ortho C?H bond activation of o-arylanilines. This paper presents a novel, simple, and efficient approach for the synthesis of benzofulvene derivatives from o-arylaniline substrates through C?H bond activation with two diarylacetylenes as an implicit benzofulvene unit. The reactivity of synthesized benzofulvenes toward oxidation was investigated, and they were shown to transform into phenanthridines, oxabenzofulvenes, and fluorescent polycyclics. (Figure presented.).

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