1203-55-0

Usage

Uses

Used in Organic Synthesis:
NAPHTHO[2,1-D]THIAZOL-2-YLAMINE is used as a key intermediate in the synthesis of various heterocyclic compounds, which are valuable building blocks for the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
NAPHTHO[2,1-D]THIAZOL-2-YLAMINE is used as a starting material for the development of novel therapeutic agents, particularly those targeting specific biological pathways or receptors. Its unique structure and reactivity make it a promising candidate for the design of new drugs with improved efficacy and selectivity.
Used in OLED Industry:
NAPHTHO[2,1-D]THIAZOL-2-YLAMINE is used as a precursor in the preparation of heteroaryl compounds, which are essential components in the fabrication of organic light-emitting diodes (OLEDs). These compounds contribute to the efficient emission of light and improved device performance in OLED applications.

InChI:InChI=1/C11H8N2S/c12-11-13-9-6-5-7-3-1-2-4-8(7)10(9)14-11/h1-6H,(H2,12,13)

Upstream product

• 540-72-7 sodium thiocyanide 
• 91-59-8 naphthalen-2-ylamine 
• 1147550-11-5 ammonium thiocyanate 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 17356-08-0 thiourea 
• 2243-58-5 2-naphthylhydrazine hydrochloride 
• 1636-33-5 2-naphthyl isothiocyanate 
• 1166-32-1 N,N'-di(2-naphthyl)thiourea 
• 521980-39-2 1-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl thiocyanate 
• 20191-75-7 1-bromo-2-naphthylamine 
• 14837-64-0 3-amino-3H-naphtho[2,1-d]thiazol-2-ylideneamine 
• 6395-99-9 naphtho[2,1-d]thiazol-2-yl-(triphenyl-λ⁵-phosphanylidene)-amine 
• 3394-04-5 naphthalen-2-yl-thiourea 
• 15192-76-4 copper(II) thiocyanate 

Downstream Products

• 26130-38-1 1-naphtho[2,1-d]thiazol-2-yl-3-phenyl-urea 
• 53338-20-8 2-aminonaphthalene-1-thiol 
• 63751-42-8 8-(2-methoxy-benzylidene)-imidazo[2,1-b]naphtho[2,1-d]thiazol-9-one 
• 63751-43-9 8-(4-isopropyl-benzylidene)-naphtho[2,1-d]imidazo[2,1-b]thiazol-9-one 
• 63751-41-7 8-(4-hydroxy-benzylidene)-imidazo[2,1-b]naphtho[2,1-d]thiazol-9-one 
• 63751-40-6 8-benzylidene-naphtho[2,1-d]imidazo[2,1-b]thiazol-9-one 
• 65323-42-4 9-(4-methoxy-phenyl)-naphtho[2,1-d]imidazo[2,1-b]thiazole 
• 56921-81-4 9-(4-ethoxy-phenyl)-naphtho[2,1-d]imidazo[2,1-b]thiazole 
• 54295-03-3 9-(4-bromo-phenyl)-imidazo[2,1-b]naphtho[2,1-d]thiazole 
• 54223-12-0 9-(4-chloro-phenyl)-imidazo[2,1-b]naphtho[2,1-d]thiazole 
• 54223-11-9 9-phenyl-imidazo[2,1-b]naphtho[2,1-d]thiazole 
• 63751-44-0 8-(4-nitro-benzylidene)-naphtho[2,1-d]imidazo[2,1-b]thiazol-9-one 
• 63751-45-1 8-(3-nitro-benzylidene)-naphtho[2,1-d]imidazo[2,1-b]thiazol-9-one 
• 63751-48-4 8-[1-(4-nitro-phenyl)-pyrrol-2-ylmethylene]-imidazo[2,1-b]naphtho[2,1-d]thiazol-9-one 

Relevant academic research and scientific papers

Visible-light-initiated malic acid-promoted cascade coupling/cyclization of aromatic amines and KSCN to 2-aminobenzothiazoles without photocatalyst

By using ambient air as the oxidant and malic acid as the promoter, a practical method for the preparation of 2-aminobenzothiazoles through visible-light-initiated cascade reaction of aromatic amines and KSCN in eco-friendly bis(methoxypropy)ether under metal-, hazardous additive-, photocatalyst-free conditions was established.

Synthesis, spectroscopic and DNA alkylating properties of malondialdehyde (MDA) bis-imine fluorescent adducts

The synthesis of a series of malondialdehyde (MDA) fluorescent adducts that mimic the well-known pentamethine cyanine dyes is reported. This new subclass of bis-imino dyes shares some common spectroscopic properties with their polymethine analogues althou

NAPHTHO[2,1 -D]THIAZOLE DERIVATIVES, COMPOSITIONS THEREOF AND METHODS OF TREATING DISORDERS

The present application relates to the compounds of formula (I) that inhibit CDK9, pharmaceutical compositions thereof and methods of making and using the same.

Visible-light photoredox catalytic approach for the direct synthesis of 2-aminobenzothiazoles from anilines

A novel, highly efficient and convenient approach for the visible-light-promoted direct synthesis of 2-aminobenzothiazoles from anilines and ammonium thiocyanate is presented. The reaction involves addition/cyclization cascade of SCN radical and anilines under photoredox catalysis with Ru(bpy)3Cl2. The salient features of the protocol include the utilization of atmospheric oxygen and visible light as clean, inexpensive and sustainable resources at room temperature.

Metal-free synthesis of 2-aminobenzothiazoles via aerobic oxidative cyclization/dehydrogenation of cyclohexanones and thioureas

A metal-free process for the synthesis of 2-aminobenzothiazoles from cyclohexanones and thioureas has been developed using catalytic iodine and molecular oxygen as the oxidant under mild conditions. Various 2-aminobenzothiazoles, 2-aminonaphtho[2,1-d]thiazoles, and 2-aminonaphtho[1,2-d] thiazoles were prepared via this method in satisfactory yields.

1-Methyl-3-phenyl-3-thiocyanato-1H,3H-quinoline-2,4-dione: A Novel Thiocyanating Agent

Under mild reaction conditions, the thiocyanato group is selectively transferred from 1-methyl-3-phenyl-3-thiocyanato-1H,3H-quinoline-2,4-dione (3) to some nucleophiles. Aliphatic primary and secondary amines are converted to S-cyanothiohydroxylamines, anilines afford p-thiocyanatoanilines, Wittig reagent is thiocyanated in α-position, and thiols are oxidized to disulfides.

PHOTOCHEMICAL SUBSTITUTION OF HALOGEN AND SO2X GROUPS BY THIOUREA AND THIOSEMICARBAZIDE. PHOTOSYNTHESIS OF AROMATIC DISULFIDES

During UV irradiation in the presence of thiourea (or thiosemicarbazide) the para- and ortho-halogen and sulfonyl derivatives of the benzene, naphthalene, and heterocyclic series with donating substituents in the ring are converted into arylisothiuronium salts.Thermal hydrolysis and oxidation of these salts lead to the formation of the respective diaryl disulfides in the case of the para isomers and thiazoles for the ortho isomers.