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1203306-05-1

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  • 3-AMinocyclopentanecarboxylic acid hydrochloride;Cyclopentanecarboxylic acid, 3-aMino-, hydrochloride

    Cas No: 1203306-05-1

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  • LEAP CHEM Co., Ltd.
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1203306-05-1 Usage

General Description

3-Aminocyclopentanecarboxylic acid hydrochloride is a chemical compound that is commonly used in pharmaceutical research and development. It is an amino acid derivative that is known to exhibit a variety of biological activities, including inhibition of the alanine aminotransferase enzyme. 3-AMinocyclopentanecarboxylic acid hydrochloride has also been studied for its potential role in reducing oxidative stress and inflammation in the body. 3-Aminocyclopentanecarboxylic acid hydrochloride is often used as a building block in the synthesis of novel pharmaceutical drugs and is considered to be a valuable tool for drug discovery and medicinal chemistry research.

Check Digit Verification of cas no

The CAS Registry Mumber 1203306-05-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,3,3,0 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1203306-05:
(9*1)+(8*2)+(7*0)+(6*3)+(5*3)+(4*0)+(3*6)+(2*0)+(1*5)=81
81 % 10 = 1
So 1203306-05-1 is a valid CAS Registry Number.

1203306-05-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Aminocyclopentanecarboxylic acid hydrochloride

1.2 Other means of identification

Product number -
Other names 3-aminocyclopentane-1-carboxylic acid,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1203306-05-1 SDS

1203306-05-1Relevant articles and documents

Design and Mechanism of Tetrahydrothiophene-Based γ-Aminobutyric Acid Aminotransferase Inactivators

Le, Hoang V.,Hawker, Dustin D.,Wu, Rui,Doud, Emma,Widom, Julia,Sanishvili, Ruslan,Liu, Dali,Kelleher, Neil L.,Silverman, Richard B.

, p. 4525 - 4533 (2015)

Low levels of γ-aminobutyric acid (GABA), one of two major neurotransmitters that regulate brain neuronal activity, are associated with many neurological disorders, such as epilepsy, Parkinson's disease, Alzheimer's disease, Huntington's disease, and cocaine addiction. One of the main methods to raise the GABA level in human brain is to use small molecules that cross the blood-brain barrier and inhibit the activity of γ-aminobutyric acid aminotransferase (GABA-AT), the enzyme that degrades GABA. We have designed a series of conformationally restricted tetrahydrothiophene-based GABA analogues with a properly positioned leaving group that could facilitate a ring-opening mechanism, leading to inactivation of GABA-AT. One compound in the series is 8 times more efficient an inactivator of GABA-AT than vigabatrin, the only FDA-approved inactivator of GABA-AT. Our mechanistic studies show that the compound inactivates GABA-AT by a new mechanism. The metabolite resulting from inactivation does not covalently bind to amino acid residues of GABA-AT but stays in the active site via H-bonding interactions with Arg-192, a π-π interaction with Phe-189, and a weak nonbonded S......O=C interaction with Glu-270, thereby inactivating the enzyme. (Figure Presented).

PYRAZOLO-PYRIMIDIN-AMINO-CYCLOALKYL COMPOUNDS AND THEIR THERAPEUTIC USES

-

Paragraph 0529, (2019/12/28)

Disclosed herein are pyrazolo-pyrimid in-ami no-cycloalkyl compounds, analogs thereof, pharmaceutical compositions comprising thereof and therapeutic uses therefor.

Enhanced enzymatic synthesis of the enantiopure intermediate for the blockbuster drug intermediate abacavir through a two-step enzymatic cascade reaction

Galla, Zsolt,Forró, Enik?,Fül?p, Ferenc

, p. 729 - 731 (2016/08/01)

A very efficient enzymatic two-step cascade reaction was devised (E?>?200) for the resolution of activated γ-lactams (±)-1 and (±)-2. The N-hydroxymethyl group worked as a traceless activating group, when the reactions were performed with H2O (0.5?equiv) in the presence of benzylamine (1?equiv) in i-Pr2O at 60?°C. The ring-opened enantiomerically pure γ-amino acids (1S,4R)-6 (ee?=?99%, intermediate of abacavir) and (1S,3R)-8 (ee?=?99%) and unreacted lactams (1S,4R)-1 and (1R,4S)-2 (ee???96%) were obtained in good yields (?43%). Treatment of (1S,4R)-1 and (1R,4S)-2 with 18% HCl or NH4OH resulted in (1R,4S)-6·HCl and (1S,3R)-8·HCl or (1S,4R)-3 and (1R,4S)-4 quantitatively, with ee???96%.

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