120642-65-1

Upstream product

• 95542-20-4 (2-aminophenyl)(5-phenyl-1H-1,2,3-triazol-4-yl)methanone 
• 300657-41-4 (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one 
• 2142-69-0 2-bromophenyl methyl ketone 
• 100-52-7 benzaldehyde 
• 26260-02-6 2-iodobenzaldehyde 
• 536-74-3 phenylacetylene 
• 1261035-55-5 1-(2-iodophenyl)-3-phenylprop-2-yn-1-one 
• 120642-66-2 3-(2-acetyl-5-phenyl-1,2,3-triazol-4-yl)-<2,1>-benzisoxazole 

Downstream Products

• 95542-20-4 (2-aminophenyl)(5-phenyl-1H-1,2,3-triazol-4-yl)methanone 
• 120642-66-2 3-(2-acetyl-5-phenyl-1,2,3-triazol-4-yl)-<2,1>-benzisoxazole 

Relevant academic research and scientific papers

Metal-free tandem reactions of 2-iodoaryl ynones with sodium azide for the synthesis of benzoisoxazole containing 1,2,3-triazoles

A metal-free approach has been developed for the synthesis of benzo[c]isoxazole (anthranils) containing 1,2,3-triazoles. The reaction proceeded efficiently through a [3 + 2] azide-alkyne cycloaddition, SNAr azidation and denitrogenative cyclization sequence. The metal-free protocol enabled effective construction of one N-O and three C-N bonds in one pot. In addition, the synthetic utility of the current methodology was further demonstrated by late stage modification of the obtained products.

Synthesis of 2,1-Benzoisoxazole-Containing 1,2,3-Triazoles through Copper-Catalyzed Three-Component Domino Reactions of o-Bromoacetophenones, Aldehydes, and Sodium Azide

We herein describe an efficient copper-catalyzed three-component domino protocol used to prepare 2,1-benzoisoxazole-containing 1,2,3-triazoles from commercially available o-bromoacetophenones, aldehydes, and sodium azide. This domino process involves Aldol condensation, copper-catalyzed azide-chalcone oxidative cyclization, 1,2,3-triazole-assisted azidation, and denitrogenative cyclization sequences. The formed compounds could be considered as benzo[c]isoxazole-functionalized combretastatin A-4 triazole analogues, which might be potential applications in the discovery of a new anticarcinogen.

2,1-benzoisoxazole derivatives as well as synthetic method and application thereof

The present invention belongs to the technical fields of organic chemistry and pharmaceutical synthesis, and specifically relates to 2,1-benzoisoxazole derivatives as well as a synthetic method and application thereof. The method comprises the following s

TRANSFORMATION OF 2-ARYLMETHYLENE-3-INOLINONES TO 4-(2-ACETYLAMINOBENZOYL)-5-ARYL-1,2,3-TRIAZOLES

2-Arylmethylene-1-acetyl-3-indolinones are converted by the action of sodium azide in a mixture of DMSO and acetic acid into 4-(2-acetylaminobenzoyl)-5-aryl-1,2,3-triazoles with yields of 87-90percent. 1-Methyl-2-phenylmethylene-3-indolinone reacts simila