120697-20-3

Basic information

• Product Name: 5-(4-methoxy-benzylidene)-imidazolidine-2,4-dione
• Synonyms: 5-(4-methoxy-benzylidene)-imidazolidine-2,4-dione
• CAS NO: 120697-20-3
• Molecular Weight: 218.212
• Mol File: 120697-20-3.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: 5-(4-methoxy-benzylidene)-imidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxy-benzylidene)-imidazolidine-2,4-dione(120697-20-3)
• EPA Substance Registry System: 5-(4-methoxy-benzylidene)-imidazolidine-2,4-dione(120697-20-3)

Safety Data

• Hazardous Substances Data: 120697-20-3(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 95378-36-2 diethyl 2,4-dioxoimidazolidin-5-yl-phosphonate 
• 461-72-3 2,4-imidazolidinedione 
• 154199-20-9 [(E)-1-Cyano-2-(4-methoxy-phenyl)-vinyl]-urea 
• 5349-42-8 (5Z)-5-(4-methoxybenzylidene)imidazolidine-2,4-dione 
• 128256-91-7 3-{4-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-1H-imidazol-2-ylsulfanyl}-pentane-2,4-dione 
• 95474-45-6 5-p-methoxybenzylidene-2-thiohydantoin 
• 107-95-9 3-amino propanoic acid 
• 154198-90-0 (E)-3-p-anisyl-2-cyano-2-propenoyl azide 
• 154198-92-2 (E)-2-Isocyanato-3-(4-methoxy-phenyl)-acrylonitrile 
• 27888-23-9 (E)-3-p-anisyl-2-cyano-2-propenoyl chloride 
• 14378-08-6 (E)-2-cyano-3-(4-methoxyphenyl)acrylic acid 
• 128256-79-1 5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-3-[(methyl-phenyl-amino)-methyl]-2-thioxo-imidazolidin-4-one 

Downstream Products

• 6318-42-9 5-(4-methoxy-benzyl)-hydantoin 
• 5349-42-8 (5Z)-5-(4-methoxybenzylidene)imidazolidine-2,4-dione 
• 54896-62-7 N-carbamoyl-O-methyl-tyrosine 
• 556-02-5 ?Tyr 
• 28030-16-2 3-(4-methoxyphenyl)-2-oxopropanoic acid 
• 112176-84-8 (E)-5-(4-methoxybenzylidene)-1,3-dimethylimidazolidine-2,4-dione 
• 1416719-84-0 (Z)-5-(4-methoxybenzylidene)-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione 

Relevant articles and documents

Enantioselective Synthesis of Chiral Substituted 2,4-Diketoimidazolidines and 2,5-Diketopiperazines via Asymmetric Hydrogenation

An enantioselective hydrogenation of 5-alkylidene-2,4-diketoimidazolidines (hydantoins) and 3-alkylidene-2,5-ketopiperazines catalyzed by the Rh/f-spiroPhos complex under mild conditions has been developed, which provides an efficient approach to the highly enantioselective synthesis of chiral hydantoins and 2,5-ketopiperazine derivatives with high enantioselectivities up to 99.9% ee.

The structural determinants for α1-adrenergic/ serotonin receptors activity among phenylpiperazinehydantoin derivatives

Several studies confirmed the reciprocal interactions between adrenergic and serotoninergic systems and the influence of these phenomena on the pathogenesis of anxiety. Hence, searching for chemical agents with a multifunctional pharmacodynamic profile may bring highly effective therapy for CNS disorders. This study presents a deep structural insight into the hydantoin-arylpiperazine group and their serotonin/α-adrenergic activity. The newly synthesized compounds were tested in the radioligand binding assay and the intrinsic activity was evaluated for the selected derivatives. The computer-aided SAR analysis enabled us to answer questions about the influence of particular structural fragments on selective vs. multifunctional activity. As a result of the performed investigations, there were two leading structures: (a) compound 12 with multifunctional adrenergic-serotonin activity, which is a promising candidate to be an effective anxiolytic agent; (b) compound 14 with high α1A/α1D affinity and selectivity towards α1B, which is recommended due to the elimination of probable cardiotoxic effect. The structural conclusions of this work provide significant support for future lead optimization in order to achieve the desired pharmacodynamic profile in searching for new CNS-modulating agents.

Synthesis of chiral hydantoin derivatives by homogeneous Pd-catalyzed asymmetric hydrogenation

5-Aryl substituted chiral hydantoin derivatives were synthesized via asymmetric hydrogenation of prochiral exocyclic alkenes using a Pd/BINAP catalyst. Moderate to good enantioselectivity were obtained (21–90% ee). A chiral Br?nsted acid additive was foun