65925-28-2

Usage

Chemical structure

A benzene ring with four substituents attached to it.

Chlorine atom

Attached to a two-carbon chain.

Two-carbon chain

Connected to another two-carbon chain and then to the benzene ring.

Bulky group

1,1,3,3-tetramethylbutyl group attached to the benzene ring.

Industrial applications

Commonly used as a solvent in various industrial applications.

Synthesis

Acts as an intermediate in the synthesis of other chemical compounds.

Safety

Important to handle with care and follow safety protocols due to potential hazards.

InChI:InChI=1/C18H29ClO2/c1-17(2,3)14-18(4,5)15-6-8-16(9-7-15)21-13-12-20-11-10-19/h6-9H,10-14H2,1-5H3

Upstream product

• 107-39-1 2,4,4-trimethyl-1-pentene 
• 2243-44-9 2-(2-phenoxyethoxy)ethyl chloride 
• 140-66-9 tert-octylphenol 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 108-95-2 phenol 

Downstream Products

• 5442-83-1 (p-tert-octylphenoxyethoxyethyl)dimethylamine 
• 854637-95-9 bis-(2-hydroxy-ethyl)-(2-{2-[4-(1,1,3,3-tetramethyl-butyl)-phenoxy]-ethoxy}-ethyl)-amine 
• 87146-74-5 1,11-bis-[4-(1,1,3,3-tetramethyl-butyl)-phenoxy]-3,9-dioxa-6-thia-undecane 
• 121-54-0 benzethonium cloride 
• 1428422-43-8 C₂₈H₄₄NO₃⁽¹⁺⁾*Cl^(1-) 

Relevant academic research and scientific papers

METHOD FOR PREPARING ARYL POLYOXY ALKYL QUATERNARY AMMONIUM COMPOUND

A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R1 is H or a C1 to C16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R2 is H or a C1 to C16 alkyl group; R3 is H or a C1 to C16 alkyl group; R4 is a C1 to C16 alkyl group; X1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

METHOD FOR PREPARATION OF ARYL POLY(OXALKYL) QUATERNARY AMMONIUM COMPOUND

A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R1 is H or a C1 to C16 alkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; R2 is H or a C1 to C16 alkyl group; R3 is H or a C1 to C16 alkyl group; R4 is a C1 to C16 alkyl group; X1 is Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production.

PHOSPHOLIPID-DETERGENT CONJUGATES AND USES THEREOF

The invention relates to novel compounds, in particular novel O-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy.