121372-79-0

Upstream product

• 66582-32-9 3-(benzyloxy)-2,2-dimethylpropan-1-ol 
• 38216-93-2 3-benzyloxypivalic aldehyde 
• 112897-03-7 3-(tert-butyldiphenylsilyloxy)-1-propanal 
• 121353-04-6 (Z)-tert-butyl(hex-3-en-1-yloxy)diphenylsilane 
• 121352-98-5 (E)-4-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-but-2-en-1-ol 
• 121352-97-4 (E)-4-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-but-2-enoic acid methyl ester 
• 121352-88-3 [(2R,3R)-3-(2-Benzyloxy-1,1-dimethyl-ethyl)-oxiranyl]-methanol 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 121353-05-7 (S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-pentanethioic acid S-(1,1-diethyl-propyl) ester 
• 100-52-7 benzaldehyde 
• 121352-95-2 2-<(4R,6S)-6-(2-benzyloxy-1,1-dimethylethyl)-2,2-dimethyl-1,3-dioxan-4-yl>ethanol 
• 111043-54-0 [(2R,3S,2'S,3'R)-3'-(2-Benzyloxy-1,1-dimethyl-ethyl)-[2,2']bioxiranyl-3-yl]-methanol 
• 121352-96-3 [(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde 

Downstream Products

• 111043-56-2 2-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-propan-1-ol 
• 121353-03-5 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-ol 
• 121353-02-4 2-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methyl-propionaldehyde 
• 111070-65-6 3-{(4S,6R)-6-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-methyl-butan-2-one 
• 121353-16-0 (R)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one 
• 121353-16-0 (S)-7-[2-(tert-Butyl-diphenyl-silanyloxy)-eth-(E)-ylidene]-2-{(4S,6R)-6-[(S)-4-(tert-butyl-diphenyl-silanyloxy)-2-methoxymethoxy-butyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-5-hydroxy-2-methyl-dec-9-en-3-one 

Relevant academic research and scientific papers

Synthesis of Bryostatins. 1. Construction of the C(1)-C(16) Fragment

The synthesis of fragment AB of bryostatin 1 is described.Two aldol coupling reactions involving (i) chiral fragment A with achiral B and (ii) chiral fragment A1 with achiral A2 constitute crucial steps in which an external chiral boron reagent is used to control stereoselectivity in the creation of a new stereogenic center.This type of double asymmetric synthesis, although rarely precedented, provides a powerful means of stereocontrol over the fragment assembly.